Jack H. Petajan

TL;DR: Exercise training resulted in improved fitness and had a positive impact on factors related to quality of life and no changes were observed for EX or NEX groups on the FSS.

TL;DR: Re recombinant human ciliary neurotrophic factor (rhCNTF) had no benefical effect on any measure of ALS progression and there were increased adverse events in the 5 μg/kg group and increased deaths.

TL;DR: There was a highly variable rate of decline within the group of patients and decline in pulmonary function most closely correlated with death, and one possible strategy is to identify and stratify patients by rate of declined pulmonary function since prospectively identifying homogeneous subgroups allows investigators to substantially reduce sample size in therapeutic trials.

TL;DR: This series of 226 patients (127 kindreds) confirms some clinical features of this disorder with notable exceptions: in this series, patients without mutations had a less typical clinical presentation including an older age at onset, no changes in diet as a precipitant, and absence of vacuolar myopathy on muscle biopsy.

TL;DR: Overall physical activity may be increased according to functional level by performing activities of dailyLiving, incorporating inefficiencies into daily living, pursuing more active recreation and eventually developing a structured exercise programme.