J
Jaclyn M. Watson
Researcher at La Trobe University
Publications - 22
Citations - 821
Jaclyn M. Watson is an academic researcher from La Trobe University. The author has contributed to research in topics: X chromosome & Monotreme. The author has an hindex of 14, co-authored 22 publications receiving 806 citations.
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X-inactivation in marsupials and monotremes
TL;DR: This review focuses mainly upon marsupial X-inactivation, the study of which has revealed differences between marsupials and eutherians in mechanisms of X- inactivation, and in the function of the system in dosage compensation and reproduction.
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Mammalian sex chromosomes: evolution of organization and function.
TL;DR: Comparisons of the sex chromosomes in these three major groups of extant mammals are reviewed, and it is shown how they have led to a new view of the evolution of mammalian sex chromosome organization and function in sex determination and X chromosome inactivation.
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The X chromosome of monotremes shares a highly conserved region with the eutherian and marsupial X chromosomes despite the absence of X chromosome inactivation.
TL;DR: It is concluded that the long arm of the human X chromosome represents a highly conserved region that formed part of the X chromosome in a mammalian ancestor at least 150 million years ago.
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Sex chromosome evolution: platypus gene mapping suggests that part of the human X chromosome was originally autosomal
TL;DR: It is reported that several genes located on the short arm of the human X chromosome are absent from the platypus X chromosomes, as well as from the marsupial X chromosome, implying that the whole human X short arm region is a relatively recent addition to the X chromosome in eutherian mammals.
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Comparative mapping identifies the fusion point of an ancient mammalian X-autosomal rearrangement.
TL;DR: The fusion point between the conserved region and the recently added regions therefore maps to human Xp11.23, although gene order on the human X indicates that there has been some rearrangement of this region.