Jacob N. Finkelstein

TL;DR: The olfactory neuronal pathway is efficient for translocating inhaled Mn oxide as solid UFPs to the central nervous system and that this can result in inflammatory changes.

TL;DR: The temporal relationship between the elevation of specific cytokines and the histological and biochemical evidence of fibrosis serves to illustrate the continuum of response, which, it is believed, underlies pulmonary radiation reactions and supports the concept of a perpetual cascade of cytokines produced immediately after irradiation.

TL;DR: In this paper, a series of experiments with ultrafine particles (approximately 20 nm) and larger particles (less than 200 nm) of "nuisance" dusts were conducted to evaluate the involvement of alveolar macrophages (AM) in particle-induced lung injury and particle translocation in rats.

TL;DR: It is concluded that cellular association is not dependent on the identity of adsorbed proteins and therefore unlikely to require specific binding to any particular cellular receptors.

TL;DR: Evaluating pulmonary effects induced in rats and mice by ultrafine particles of known high toxicity in order to obtain information on principles of ultrafine particle toxicology found that the pulmonary toxicity of the ultrafine Teflon fumes could be prevented by adapting the animals with short 5-minute exposures on 3 days prior to a 15-minute exposure.