Welding Metallurgy of

Preferential inhibition by (-)-epigallocatechin-3-gallate of the cell surface NADH oxidase and growth of transformed cells in culture.

It is found out that an antibody against AILIM (also called ICOS and 8F4) significantly inhibits the onset of inflammatory bowel diseases (in particular, Crohn's disease and colitis such as ulcerative colitis) and that this antibody exerts a significant therapeutic effect on various inflammatory bowel diseases.

Remedies for inflammatory bowel diseases

An antibody against AILIM (alternatively called JTT-1 antigen, JTT-2 antigen, ICOS and 8F4) was found to have a significant therapeutic effect on arthrosis, for example, rheumatoid arthritis and osteoarthritis, graft versus host disease, graft immune rejection, inflammation (hepatitis and inflammatory bowel diseases), diseased condition accompanied by the excessive production of an antibody against a foreign antigen triggered by immunological sensitization by the antigen.

A pharmaceutical composition for treating immune diseases

Ring-closing metathesis (RCM) of peptides often requires insertion of allylglycines at the intended sites of ring juncture, which can result in the displacement of residues that are needed for biological activity. This type of side-chain deletion can be avoided by appending beta-vinyl substituents onto the parent residues at the intended sites of ring juncture, thereby effectively converting them into functionalized allylglycine equivalents. Such an approach has been previously applied in modified form to growth-factor receptor bound 2 (Grb2) SH2 domain-binding peptides by using an N-terminal beta-vinyl-functionalized phosphotyrosyl mimetic and C-terminal 2-allyl-3-aryl-1-propanamides that lacked the alpha-carboxyl portion of allylglycine residues. These C-terminal moieties involved lengthy synthesis and once prepared, required an individual total synthesis of each final macrocycle. Work reported herein significantly enhances the versatility of the original approach through the use of C-terminal allylglycine amides that can be prepared from commercially available L- and D-allylglycines and suitable amines. This methodology could be generally useful where macrocylization is desired with maintenance of functionality at a site of ring juncture.

Ring-closing metathesis of C-terminal allylglycine residues with an N-terminal β-vinyl-substituted phosphotyrosyl mimetic as an approach to novel Grb2 SH2 domain-binding macrocycles

A screening method of SH2 domain ligands and blockers using a solid phase binding

Generally, molds are fabricated by the machining of massive billets of tool steels, such as AISI4140 or H13, but it has drawbacks, such as a large material loss and long-delivery time. The Wire-Arc Additive Manufacturing (WAAM) process could be an alternative fabrication method. It has the advantages of less material loss, short-delivery time, and the chance to make a reinforced mold using dissimilar materials. 5 Cr - 4 Mo steel wire has high potential to produce molds via the WAAM process. This is a commercial tool steel solid wire initially designed for the repair and modification of tools and molds that has superior hot wear resistance and toughness. However, no study has examined the WAAM of tool steels, even though it has high potential and advantages. Shielding gas has a significant effect on the performance of the WAAM process, which is based on gas metal arc welding (GMAW). Argon (an inert gas) and carbon dioxide (a reactive gas) are generally used for the GMAW of steel alloys, and they are frequently used as mixed gases at various ratios. Shielding gases have a significant influence on the arc stability, weld quality, and formation of weld defects. Therefore, using a proper shielding gas for the material and process is important to sound WAAM performance. This paper discusses the effect of the shielding gas on the additive manufacturability of tool steel, as a first step for the WAAM of die casting molds. The experiments were conducted with two different shielding gases, M21 (Ar + 18% CO2) and C1 (100% CO2). The use of C1 showed neither surface contamination nor internal defects, and resulted in a larger amount of deposition than the M21.
(Received July 8, 2020; Accepted October 15, 2020)

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Effect of Shielding Gases on the Wire Arc Additive Manufacturability of 5 Cr – 4 Mo Tool Steel for Die Casting Mold Making

In this study, the effects of electrode surface design on the resistance spot weldability and degradation of the electrode following resistance spot welding (RSW) of aluminum 6014-T4 alloy were investigated. A new patterning method that can be produced through repetitive pressurization was applied to the electrode, producing a lattice-like pattern shape on the resulting patterned electrode. When RSW was performed using the lattice patterned electrode, the contact resistance decreased because of the effective removal of the oxide film from the surface of the aluminum alloy. As a result, heat generated by resistance on the E/S interface was reduced. Moreover, the growth rate of the weld nuggets formed with the patterned electrode in the thickness direction was lower than that of the nuggets formed with the as-received electrode, and there was comparatively less Cu-Al alloying of the patterned electrode. In addition, a continuous RSW process was performed on the alloy to observe the effect of the electrode surface design on electrode sticking. The results indicated that electrode surface shape can significantly influence resistance heat generation and electrode cooling effects, as well as produce welds with different weld morphology and microstructure. Finally, it was proved that the patterned electrode suffered less electrode degradation through EPMA on the electrode surface after the continuous RSW was completed. (Received September 14, 2020; Accepted November 12, 2020)

/pdf/effect-of-electrode-patterning-on-melting-behavior-and-1njg1isvrj.pdf

Jae Won Kim

Papers

A screening method of SH2 domain ligands and blockers using a solid phase binding

Effect of Shielding Gases on the Wire Arc Additive Manufacturability of 5 Cr – 4 Mo Tool Steel for Die Casting Mold Making

Effect of Electrode Patterning on Melting Behavior and Electrode Degradation in Resistance Spot Welding of A6014-T4 Alloy

A screening method for Src homology 3 domain binding blockers based on ras signaling pathway