J
Jae Won Lee
Researcher at University of Ulsan
Publications - 80
Citations - 4082
Jae Won Lee is an academic researcher from University of Ulsan. The author has contributed to research in topics: Monetary policy & Inflation targeting. The author has an hindex of 25, co-authored 80 publications receiving 3491 citations. Previous affiliations of Jae Won Lee include University of Virginia & Rutgers University.
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Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung.
TL;DR: Treatment with allogeneic human MSCs or the conditioned medium restores normal fluid balance in an ex vivo perfused human lung injured by E. coli endotoxin.
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Human Mesenchymal Stem Cell Microvesicles for Treatment of Escherichia coli Endotoxin-Induced Acute Lung Injury in Mice
Ying-gang Zhu,Xiaomei Feng,Jason Abbott,Xiaohui Fang,Qi Hao,Antoine Monsel,Jie-Ming Qu,Michael A. Matthay,Jae Won Lee +8 more
TL;DR: Human MSC‐derived MVs were therapeutically effective following E. coli endotoxin‐induced ALI in mice in part through the expression of KGF mRNA in the injured alveolus.
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Concise Review: Mesenchymal Stem Cells for Acute Lung Injury: Role of Paracrine Soluble Factors†‡§
TL;DR: This review will focus on recent studies, which support the potential therapeutic use of MSCs in ALI/ARDS, with an emphasis on the role of paracrine soluble factors.
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Therapeutic Effects of Human Mesenchymal Stem Cell–derived Microvesicles in Severe Pneumonia in Mice
Antoine Monsel,Ying-gang Zhu,Stéphane Gennai,Qi Hao,Shuling Hu,Jean-Jacques Rouby,Michelle Rosenzwajg,Michael A. Matthay,Jae Won Lee +8 more
TL;DR: Administration of MVs derived from human MSCs improved survival in part through keratinocyte growth factor secretion and decreased the influx of inflammatory cells, cytokines, protein, and bacteria in mice injured with bacterial pneumonia.
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Therapeutic effects of human mesenchymal stem cells in ex vivo human lungs injured with live bacteria.
Jae Won Lee,Anna Krasnodembskaya,David H. McKenna,Yuanlin Song,Jason Abbott,Michael A. Matthay +5 more
TL;DR: Clinical-grade human mesenchymal stem cells restored alveolar fluid clearance to a normal level, decreased inflammation, and were associated with increased bacterial killing and reduced bacteremia, in part through increasedAlveolar macrophage phagocytosis and secretion of antimicrobial factors.