Showing papers by "Jaime S. Brahim published in 2001"
TL;DR: Data indicate that peripheral opioid analgesia can be evoked in a model of chronic, but not acute, inflammatory pain, suggesting a temporal dependent mechanism needed for the expression of peripheral opiate analgesia during inflammation in humans.
Abstract: A series of double-blind, placebo-controlled clinical trials demonstrated that low doses of morphine (0.4, 1.2, and 3.6 mg) administered into the intraligamentary space of a chronically inflamed hyperalgesic tooth produced a dose-related naloxone-reversible analgesia. This analgesic effect is mediated by a local mechanism in the inflamed tissue, because subcutaneous administration of a 1.2 mg dose of morphine failed to elicit an analgesic response. In contrast, submucosal administration of 1.2 mg morphine or 50 microg fentanyl to the site of extraction of an impacted third molar after the onset of acute pain failed to elicit an analgesic response despite demonstration of a sensitive bioassay. These data indicate that peripheral opioid analgesia can be evoked in a model of chronic, but not acute, inflammatory pain, suggesting a temporal dependent mechanism needed for the expression of peripheral opiate analgesia during inflammation in humans.
94 citations
TL;DR: Assessment of oral and craniofacial findings in a cohort of patients with Fabry's disease found a variety of abnormalities, including an increased prevalence of cysts/pseudocysts of the maxillary sinuses and the presence of maxillary prognathism.
Abstract: Objective: Fabry's disease is an X-linked metabolic disease caused by the deficiency of the lysosomal enzyme α-galactosidase A. The purpose of this study was to assess oral and craniofacial findings in a cohort of patients with Fabry's disease to facilitate recognition of this condition and early treatment of its manifestations. Study Design: This is a case series describing oral and craniofacial findings of 13 male patients diagnosed with Fabry's disease. Data were collected by means of a standardized questionnaire, clinical examination, panoramic and cephalometric radiographs, and magnetic resonance imaging. Results: A variety of abnormalities are described, including an increased prevalence of cysts/pseudocysts of the maxillary sinuses (PCMs) and the presence of maxillary prognathism. Conclusion: Given the high prevalence of oral and dental abnormalities, we recommend a thorough stomatologic evaluation of these patients. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001;92:415-9)
33 citations