J
Jakir Hossain
Researcher at University of New South Wales
Publications - 9
Citations - 121
Jakir Hossain is an academic researcher from University of New South Wales. The author has contributed to research in topics: Innate immune system & TLR2. The author has an hindex of 6, co-authored 9 publications receiving 92 citations. Previous affiliations of Jakir Hossain include University of Nottingham.
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Journal ArticleDOI
The Soluble Form of Toll-Like Receptor 2 Is Elevated in Serum of Multiple Sclerosis Patients: A Novel Potential Disease Biomarker.
Jakir Hossain,Elena Morandi,Radu Tanasescu,Nanci Frakich,Marzia Caldano,David Onion,Tola A. Faraj,Clett Erridge,Clett Erridge,Bruno Gran,Bruno Gran +10 more
TL;DR: Results indicate that two different markers of TLR 2-activity—urinary TLR2-stimulants and serum sTLR2 levels—are significantly elevated in MS patients compared to HC.
Journal ArticleDOI
Innate immune regulation of autoimmunity in multiple sclerosis: Focus on the role of Toll-like receptor 2.
TL;DR: This review discusses innate regulation of autoimmunity in MS with a focus on the role of TLR2 signaling, a member of the TLR family that forms heterodimers with either TLR1 or TLR6 and detects a wide range of microbial as well as self-derived molecular structures.
Book ChapterDOI
Delineating the Role of Toll-Like Receptors in the Neuro-inflammation Model EAE
TL;DR: This chapter outlines different methods employed in the labs to investigate the role of TLRs in EAE model and some studies demonstrated the immune adjuvant properties of certain TLR ligands including TLR2, TLR4, and TLR9 in Eae.
Journal ArticleDOI
Evidence of Altered Peripheral Nerve Function in a Rodent Model of Diet-Induced Prediabetes.
Jakir Hossain,Michael D. Kendig,Brandon M. Wild,Tushar Issar,Arun V. Krishnan,Margaret J. Morris,Ria Arnold +6 more
TL;DR: It is shown that prediabetic rats over-consuming processed, palatable foods demonstrated altered nerve function that preceded overt PN, which provides a relevant model for pathophysiological investigation of diabetic complications.
Journal ArticleDOI
Polymer brush based fluorescent immunosensor for direct monitoring of interleukin-1β in rat blood
Fei Deng,Yi Li,Jakir Hossain,Michael D. Kendig,Ria Arnold,Ewa M. Goldys,Margaret J. Morris,Guozhen Liu +7 more
TL;DR: This device was validated by detection of IL-1β in rat whole blood samples with greater concentrations observed in obese rats compared to control, and strong positive correlation between concentrations of IL,1β and blood glucose, suggesting this device is feasible for direct detection of target analytes in biological samples.