J
James B. Mangum
Researcher at Research Triangle Park
Publications - 32
Citations - 1673
James B. Mangum is an academic researcher from Research Triangle Park. The author has contributed to research in topics: Lung & Bronchoalveolar lavage. The author has an hindex of 17, co-authored 32 publications receiving 1588 citations.
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Journal ArticleDOI
Pulmonary responses of mice, rats, and hamsters to subchronic inhalation of ultrafine titanium dioxide particles.
Edilberto Bermudez,James B. Mangum,Brian A. Wong,Bahman Asgharian,Paul M. Hext,David B. Warheit,Jeffrey I. Everitt +6 more
TL;DR: There were significant species differences in the pulmonary responses to inhaled uf-TiO(2) particles, including inflammation, cytotoxicity, lung cell proliferation, and histopathological alterations in rats, mice, and hamsters.
Journal ArticleDOI
Long-Term Pulmonary Responses of Three Laboratory Rodent Species to Subchronic Inhalation of Pigmentary Titanium Dioxide Particles
Edilberto Bermudez,James B. Mangum,Bahman Asgharian,Brian A. Wong,Edward E. Reverdy,Derek B. Janszen,Paul M. Hext,David B. Warheit,Jeffrey I. Everitt +8 more
TL;DR: Under conditions in which the lung p-TiO(2) burdens were similar and likely to induce pulmonary overload, rats developed a more severe and persistent pulmonary inflammatory response than either mice or hamsters.
Journal ArticleDOI
Single-walled carbon nanotube (SWCNT)-induced interstitial fibrosis in the lungs of rats is associated with increased levels of PDGF mRNA and the formation of unique intercellular carbon structures that bridge alveolar macrophages in situ.
James B. Mangum,Elizabeth A Turpin,Aurita Antao-Menezes,Mark F. Cesta,Edilberto Bermudez,James C. Bonner +5 more
TL;DR: The findings indicate that SWCNT do not cause lung inflammation and yet induce the formation of small, focal interstital fibrotic lesioins in the alveolar region of the lungs of rats.
Journal ArticleDOI
Ultrafine carbon black particles enhance respiratory syncytial virus-induced airway reactivity, pulmonary inflammation, and chemokine expression.
TL;DR: A synergistic effect of ultrafine CB particles on RSV infection is demonstrated, and a potential mechanism for increased respiratory infections in human populations after PM exposure is suggested.
Journal ArticleDOI
Antioxidant defense mechanisms in cultured pleural mesothelial cells.
TL;DR: Investigation of the role of different antioxidant pathways in cultured rat pleural mesothelial cells suggested that the results of the catalase-inhibition studies are probably not due to a change in the characteristics of the cells in culture, and 3-Aminobenzamide is known to prevent NAD depletion through inhibition of poly(ADP-ribose) polymerase during oxidant stress.