James B. Skatrud

TL;DR: It is concluded that bilateral lung transplantation abolished expression of the reflex in humans, and that in normal intact humans the duration of expiratory prolongation with lung inflation is prolonged by alveolar hypocapnia.

TL;DR: It is concluded that poststimulus hyperpnea occurs in NREM sleep as long as hypoxia is brief and arterial PCO2 is maintained, suggesting the activation of the afterdischarge mechanism.

TL;DR: Chronic CO (2) retention in patients with chronic ventilatory failure is attributed to alterations in respiratory cycle timing and to a neuromuscular inspiratory effort which is adequate for the level of tissue CO(2) production, but inadequate in the presence of mechanical and ventilation-perfusion abnormalities to normalize arterial blood gases.

TL;DR: It is concluded that, during non-rapid eye movement sleep, carotid chemoreceptors are required to produce apneas that normally occur after a transient ventilatory overshoot and for PB.

TL;DR: To determine if phasic respiratory muscle activity can be inhibited during nocturnal mechanical ventilation, and the mechanism by which this inhibition occurs, twelve normal subjects were studied during NREM sleep and during spontaneous breathing.