J
James E. Strickler
Researcher at Smith, Kline & French
Publications - 39
Citations - 6130
James E. Strickler is an academic researcher from Smith, Kline & French. The author has contributed to research in topics: Protease & Binding protein. The author has an hindex of 23, co-authored 39 publications receiving 6036 citations. Previous affiliations of James E. Strickler include Albert Einstein College of Medicine & Cetus Corporation.
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Journal ArticleDOI
A protein kinase involved in the regulation of inflammatory cytokine biosynthesis.
Joseph C. Lee,Jeffrey T. Laydon,Peter C. McDonnell,Timothy Gallagher,Sanjay Kumar,David W. Green,Dean E. McNulty,M. J. Blumenthal,J. R. Heys,S. W. Landvatter,James E. Strickler,Megan M. McLaughlin,I. R. Siemens,Seth M. Fisher,George P. Livi,John R. White,Jerry L. Adams,Peter Young +17 more
TL;DR: Production of interleukin-1 and tumour necrosis factor from stimulated human monocytes is inhibited by a new series of pyridinyl-imidazole compounds, suggesting that the CSBPs are critical for cytokine production.
Journal ArticleDOI
Molecular cloning of the complementary dna for human tumor necrosis factor
Alice M. Wang,Abla A. Creasey,M. B. Ladner,Leo S. Lin,James E. Strickler,JN Van Arsdell,R Yamamoto,David F. Mark +7 more
TL;DR: Human TNF was purified to apparent homogeneity as a 17.3-kilodalton protein from HL-60 leukemia cells and showed cytotoxic and cytostatic activities against various human tumor cell lines.
Journal ArticleDOI
Human immunodeficiency virus protease expressed in Escherichia coli exhibits autoprocessing and specific maturation of the gag precursor
Christine Debouck,Joselina G. Gorniak,James E. Strickler,Thomas D. Meek,Brian W. Metcalf,Martin Rosenberg +5 more
TL;DR: This system will allow detailed structure-function analysis of the HIV protease and provides a simple assay for the development of potential therapeutic agents directed against this critical viral enzyme.
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Inhibition of HIV-1 protease in infected T-lymphocytes by synthetic peptide analogues.
Thomas D. Meek,Dennis M. Lambert,Geoffrey B. Dreyer,Thomas Joseph Carr,Thaddeus A. Tomaszek,Michael L. Moore,James E. Strickler,Christine Debouck,Lawrence J. Hyland,Thomas J. Matthews,Brian W. Metcalf,S. R. Petteway +11 more
TL;DR: It is demonstrated that synthetic peptide analogues, which are potent inhibitors of purified HIV-1 protease, inhibit the processing of the viral polyproteins in cultures of HIV- 1-infected T lymphocytes and attenuate viral infectivity.
Journal ArticleDOI
Inhibition of human immunodeficiency virus 1 protease in vitro: rational design of substrate analogue inhibitors
Geoffrey B. Dreyer,Brian W. Metcalf,Thaddeus A. Tomaszek,Thomas Joseph Carr,Chandler Ac rd,Lawrence J. Hyland,Stephen A. Fakhoury,Victoria W. Magaard,Michael L. Moore,James E. Strickler +9 more
TL;DR: Inhibitors of the protease from human immunodeficiency virus 1 (HIV-1) were designed, synthesized, and kinetically characterized and effectively blocked the proteolytic processing of a recombinant form of Pr55gag by HIV-1 protease in a cell-free assay.