J
James G. Kench
Researcher at Royal Prince Alfred Hospital
Publications - 234
Citations - 30076
James G. Kench is an academic researcher from Royal Prince Alfred Hospital. The author has contributed to research in topics: Cancer & Prostate cancer. The author has an hindex of 64, co-authored 213 publications receiving 24889 citations. Previous affiliations of James G. Kench include Royal North Shore Hospital & Westmead Hospital.
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Journal ArticleDOI
A role for GATA-2 in transition to an aggressive phenotype in prostate cancer through modulation of key androgen-regulated genes.
Maret Böhm,Warwick J. Locke,R. L. Sutherland,James G. Kench,James G. Kench,Susan M. Henshall +5 more
TL;DR: The results indicate that upregulation of GATA-2 may contribute to the progression to aggressive prostate cancer through modulation of expression of AR and key androgen-regulated genes, one of which, AZGP1, is associated with the progression with metastatic disease.
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Zinc-alpha2-glycoprotein Expression as a Predictor of Metastatic Prostate Cancer Following Radical Prostatectomy
Susan M. Henshall,Lisa G. Horvath,David I. Quinn,Sarah A. Eggleton,John J. Grygiel,Phillip D. Stricker,Andrew V. Biankin,James G. Kench,Robert L. Sutherland +8 more
TL;DR: If these preliminary findings are validated in independent cohorts, the measurement of AZGP1 levels in radical prostatectomy specimens may permit an accurate and timely assessment of risk of metastatic progression after radical prostateCTomy.
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Myositis associated with a newly described microsporidian, Trachipleistophora hominis, in a patient with AIDS.
Andrew S. Field,Deborah Marriott,Sam Milliken,Bruce J. Brew,E U Canning,James G. Kench,P. Darveniza,J. Harkness +7 more
TL;DR: The first case of a Pleistophora sp.-like microsporidian infection presenting as a progressive severe myosotis associated with fever and weight loss is reported, and a new genus and species, Trachipleistophoras hominis, has been established for this parasite.
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Loss of mammary epithelial prolactin receptor delays tumor formation by reducing cell proliferation in low-grade preinvasive lesions.
Samantha R. Oakes,Fiona G. Robertson,James G. Kench,Margaret Gardiner-Garden,Matt P. Wand,Jeffrey E. Green,Christopher J. Ormandy +6 more
TL;DR: Targeting of mammary prolactin signaling thus provides a strategy to prevent the early progression of neoplasia to invasive carcinoma, and act directly on the mammary epithelial cells to increase cell proliferation in preinvasive lesions.
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Androgen regulation of multidrug resistance-associated protein 4 (MRP4/ABCC4) in prostate cancer.
Lye Lin Ho,James G. Kench,James G. Kench,David J. Handelsman,George L. Scheffer,Phillip D. Stricker,John G. Grygiel,Robert L. Sutherland,Susan M. Henshall,John F. Allen,Lisa G. Horvath +10 more
TL;DR: The pattern of MRP4/ABCC4 expression in normal and malignant prostate tissue and the relationship of MRp4/ ABCC4expression and function in response to androgen signaling are defined.