James H. Schick

TL;DR: Evidence for a major ARMD locus on 15q21, which, coupled with numerous other loci segregating in these families, suggests complex oligogenic patterns of inheritance for ARMD.

TL;DR: In this paper, the authors explored common genetic influences on speech-sound disorder and reading, and examined linkage for several quantitative traits to markers in the pericentrometric region of chromosome 3 in 77 families ascertained through a child with SSD.

TL;DR: A 14-cM region on chromosome 12, near D12S346 (located at 106.89 cM), showed the strongest indication of linkage, with a P value of .004, and three other regions, on chromosomes 5, 6, and 15, that were nominally significant at P ≤.01 are also appropriate for fine mapping.

TL;DR: There is evidence for a major ARMD locus on 15q21, which, coupled with numerous other loci segregating in these families, suggests complex oligogenic patterns of inheritance for ARMD.

TL;DR: The current genome scan for age-related cortical cataracts may lead to identification of novel genes, because few regions identified in the current scan have previously been implicated in congenital or age- related cataract.