J
James Hofrichter
Researcher at National Institutes of Health
Publications - 103
Citations - 15268
James Hofrichter is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Protein folding & Polymerization. The author has an hindex of 62, co-authored 102 publications receiving 14725 citations.
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Journal ArticleDOI
Folding dynamics and mechanism of β-hairpin formation
TL;DR: In this article, the authors used a nanosecond laser temperature-jump apparatus to study the kinetics of folding a β-hairpin consisting of 16 amino-acid residues, which is also the basic component of antiparallel β-sheets.
Journal ArticleDOI
The protein folding 'speed limit'.
TL;DR: The predicted limits suggest that most known ultrafast folding proteins can be engineered to fold more than ten times faster, with alpha proteins folding faster than beta or alphabeta.
Book ChapterDOI
Sickle cell hemoglobin polymerization.
TL;DR: The chapter discusses the thermodynamic and kinetic studies of solutions, and includes a description of the nonideal behavior of concentrated hemoglobin S solutions and the effects of physiologically relevant variables, especially oxygen, and the presence of non-S hemoglobins on the polymerization process.
Book ChapterDOI
[8] Singular value decomposition: Application to analysis of experimental data
Eric R. Henry,James Hofrichter +1 more
TL;DR: The chapter describes the way in which the singular value decomposition of a noise-free data set for which the spectra, f, and concentration, c, vectors are known can be calculated from consideration of the integrated overlaps of these components.
Journal ArticleDOI
The role of solvent viscosity in the dynamics of protein conformational changes
TL;DR: The theory and experiment suggest that the dominant factor in markedly reducing the rate of conformational changes in myoglobin at low temperatures is the very high viscosity of the glycerol-water solvent.