J
James K.J. Diss
Researcher at University College London
Publications - 30
Citations - 1909
James K.J. Diss is an academic researcher from University College London. The author has contributed to research in topics: Cancer & Gene expression. The author has an hindex of 18, co-authored 30 publications receiving 1757 citations. Previous affiliations of James K.J. Diss include Imperial College London.
Papers
More filters
Journal ArticleDOI
Voltage-Gated Sodium Channel Expression and Potentiation of Human Breast Cancer Metastasis
Scott P. Fraser,James K.J. Diss,Athina-Myrto Chioni,Maria E. Mycielska,Huiyan Pan,Rezan Fahrioglu Yamaci,Filippo Pani,Zuzanna S. Siwy,Monika Krasowska,Zbigniew J. Grzywna,William J. Brackenbury,Dimis Theodorou,Meral Koyutürk,Handan Kaya,Esra Battaloglu,Manuela Tamburo De Bella,Martin J. Slade,Robert S. Tolhurst,Carlo Palmieri,Jie Jiang,David S. Latchman,R. Charles Coombes,Mustafa B. A. Djamgoz +22 more
TL;DR: Investigating voltage-gated Na+ channel expression and its possible role in human breast cancer found up-regulation of neonatal Nav1.5 protein in its newly identified “neonatal” splice form could serve both as a novel marker of the metastatic phenotype and a therapeutic target.
Journal ArticleDOI
A potential novel marker for human prostate cancer: voltage-gated sodium channel expression in vivo.
James K.J. Diss,D. Stewart,Filippo Pani,Christopher S. Foster,Marjorie M. Walker,Alpesh Patel,Mustafa B. A. Djamgoz +6 more
TL;DR: It is concluded that VGSCα expression increases significantly in CaP in vivo and that Nav1.7 is a potential functional diagnostic marker.
Journal ArticleDOI
The neonatal splice variant of Nav1.5 potentiates in vitro invasive behaviour of MDA-MB-231 human breast cancer cells.
TL;DR: It was concluded that nNav1.5 is primarily responsible for the VGSC-dependent enhancement of invasive behaviour in MDA-MB-231 cells and may be useful in clinical management of metastatic BCa.
Journal ArticleDOI
Expression profiles of voltage-gated Na(+) channel alpha-subunit genes in rat and human prostate cancer cell lines.
TL;DR: Voltage‐gated Na+ channel activity has been implicated in prostate cancer metastasis and the gene(s) responsible for the functional VGSCα expression in strongly metastatic PC cell lines is not known.
Journal ArticleDOI
Voltage-gated Na+ channels: multiplicity of expression, plasticity, functional implications and pathophysiological aspects.
TL;DR: This article reviews recent literature that has contributed to the understanding of how individual VGSC subtypes can generate their unique physiological signatures within different cell types and highlights emerging areas of interest, in particular the finding of multiple expression of individual VG SC subtypes within single cells.