S
Scott P. Fraser
Researcher at Imperial College London
Publications - 71
Citations - 3789
Scott P. Fraser is an academic researcher from Imperial College London. The author has contributed to research in topics: Cancer & Cancer cell. The author has an hindex of 30, co-authored 69 publications receiving 3428 citations. Previous affiliations of Scott P. Fraser include Rowett Research Institute & Seoul National University.
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Journal ArticleDOI
Voltage-Gated Sodium Channel Expression and Potentiation of Human Breast Cancer Metastasis
Scott P. Fraser,James K.J. Diss,Athina-Myrto Chioni,Maria E. Mycielska,Huiyan Pan,Rezan Fahrioglu Yamaci,Filippo Pani,Zuzanna S. Siwy,Monika Krasowska,Zbigniew J. Grzywna,William J. Brackenbury,Dimis Theodorou,Meral Koyutürk,Handan Kaya,Esra Battaloglu,Manuela Tamburo De Bella,Martin J. Slade,Robert S. Tolhurst,Carlo Palmieri,Jie Jiang,David S. Latchman,R. Charles Coombes,Mustafa B. A. Djamgoz +22 more
TL;DR: Investigating voltage-gated Na+ channel expression and its possible role in human breast cancer found up-regulation of neonatal Nav1.5 protein in its newly identified “neonatal” splice form could serve both as a novel marker of the metastatic phenotype and a therapeutic target.
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Directional movement of rat prostate cancer cells in direct-current electric field: involvement of voltagegated Na+ channel activity.
Mustafa B. A. Djamgoz,Maria E. Mycielska,Maria E. Mycielska,Zbigniew Madeja,Scott P. Fraser,Włodzimierz Korohoda +5 more
TL;DR: The results showed that the highly metastatic MAT-LyLu cells responded to the application of the electric field strongly by migrating towards the cathode, which is consistent with functional voltage-gated Na+ channel expression occurring specifically inhighly metastatic cells.
Journal Article
Expression and functional analysis of voltage-activated Na+ channels in human prostate cancer cell lines and their contribution to invasion in vitro.
Marc Laniado,El-Nasir Lalani,Scott P. Fraser,J.A. Grimes,Gurjeet Bhangal,Mustafa B. A. Djamgoz,Paul D. Abel +6 more
TL;DR: Tetrodotoxin reduced the invasiveness of PC-3 but not LNCaP cells, and these data suggest that ion channels may play an important functional role in tumor invasion.
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Differential expression of voltage-activated Na+ currents in two prostatic tumour cell lines: contribution to invasiveness in vitro
J.A. Grimes,Scott P. Fraser,Gary J. Stephens,J. E. G. Downing,Marc Laniado,Christopher S. Foster,Paul D. Abel,Mustafa B. A. Djamgoz +7 more
TL;DR: The voltage‐gated ionic currents of two rodent prostatic cancer cell lines were investigated using the whole‐cell patch clamp technique and tetrodotoxin had no effect on the invasiveness of the AT‐2 cells.
Journal ArticleDOI
Contribution of functional voltage‐gated Na+ channel expression to cell behaviors involved in the metastatic cascade in rat prostate cancer: I. lateral motility
Scott P. Fraser,V. Salvador,E.A. Manning,J. Mizal,S. Altun,M. Raza,R.J. Berridge,Mustafa B. A. Djamgoz +7 more
TL;DR: The results, taken together, would suggest strongly that functional VGSC expression enhances cellular motility of PCa cells.