James Kim

TL;DR: Using a high-resolution screen for DNA copy-number alterations in Wilms tumor, somatic deletions targeting a previously uncharacterized gene on the X chromosome are identified and called WTX, which is inactivated in approximately one-third of Wilms tumors.

TL;DR: A subset of IDH-mutant gliomas with mutations in driver oncogenes has a more malignant phenotype in patients, and identification of these alterations may provide an opportunity for use of targeted therapies in these patients.

TL;DR: Autologous, but not heterologous MSCs showed multiple immunoregulatory properties in vitro and delayed allograft rejection in vivo when co-transplanted with islets; however, they failed to prevent rejection when injected systemically.

TL;DR: ATF-2 mutant mice proved more susceptible to death than control mice from LPS plus D-galactosamine injection or Coxsackievirus B3 infection and had a higher incidence of mononuclear pulmonary infiltrates after exposure to Herpes simplex virus-1.

TL;DR: The single most sensitive test to identify astrocytoma is fluorescence insitu hybridization for chromosome 7 gain (76.2%) and the combination of p53 and mutant IDH1 IHC provides a higher sensitivity than either test alone (47.4%) and offers a practical initial approach for the surgical pathologist.