S
Shota Tanaka
Researcher at University of Tokyo
Publications - 172
Citations - 2742
Shota Tanaka is an academic researcher from University of Tokyo. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 22, co-authored 115 publications receiving 2113 citations. Previous affiliations of Shota Tanaka include Brigham and Women's Hospital & Harvard University.
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Journal ArticleDOI
Extreme Vulnerability of IDH1 Mutant Cancers to NAD+ Depletion
Kensuke Tateishi,Hiroaki Wakimoto,A. John Iafrate,Shota Tanaka,Franziska Loebel,Nina Lelic,Dmitri Wiederschain,Olivier Bedel,Gejing Deng,Bailin Zhang,Timothy He,Xu Shi,Robert E. Gerszten,Yiyun Zhang,Jing-Ruey J. Yeh,William T. Curry,Dan Zhao,Sudhandra Sundaram,Fares Nigim,Mara V.A. Koerner,Quan H Ho,David E. Fisher,Elisabeth Roider,Lajos Kemény,Yardena Samuels,Keith T. Flaherty,Tracy T. Batchelor,Andrew S. Chi,Daniel P. Cahill +28 more
TL;DR: It is found that 2-HG depletion did not inhibit growth of several IDH1 mutant solid cancer types, and NAD+ depletion is identified as a metabolic susceptibility of IDH 1 mutant cancers.
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Diagnostic and therapeutic avenues for glioblastoma: no longer a dead end?
TL;DR: Common molecular alterations relevant to the biology of glioblastomas, targeted, antiangiogenic and immunotherapies that have impacted on the treatment of this disease, and the challenges and pitfalls associated with these therapies are discussed.
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A combination of TERT promoter mutation and MGMT methylation status predicts clinically relevant subgroups of newly diagnosed glioblastomas
Hideyuki Arita,Hideyuki Arita,Kai Yamasaki,Yuko Matsushita,Taishi Nakamura,Taishi Nakamura,Asanao Shimokawa,Hirokazu Takami,Hirokazu Takami,Shota Tanaka,Akitake Mukasa,Mitsuaki Shirahata,Saki Shimizu,Kaori Suzuki,Kuniaki Saito,Keiichi Kobayashi,Fumi Higuchi,Takeo Uzuka,Ryohei Otani,Kaoru Tamura,Kazutaka Sumita,Makoto Ohno,Yasuji Miyakita,Naoki Kagawa,Naoya Hashimoto,Ryusuke Hatae,Koji Yoshimoto,Naoki Shinojima,Hideo Nakamura,Yonehiro Kanemura,Yoshiko Okita,Manabu Kinoshita,Kenichi Ishibashi,Tomoko Shofuda,Yoshinori Kodama,Kanji Mori,Yusuke Tomogane,Junya Fukai,Koji Fujita,Yuzo Terakawa,Naohiro Tsuyuguchi,Shusuke Moriuchi,Masahiro Nonaka,Hiroyoshi Suzuki,Makoto Shibuya,Taketoshi Maehara,Nobuhito Saito,Motoo Nagane,Nobutaka Kawahara,Keisuke Ueki,Toshiki Yoshimine,Etsuo Miyaoka,Ryo Nishikawa,Takashi Komori,Yoshitaka Narita,Koichi Ichimura +55 more
TL;DR: The findings suggest that a combination of IDH, TERT, and MGMT refines the classification of grade II-IV diffuse gliomas, and patients with TERT mutant-MGMT unmethylated GBM have the poorest prognosis.
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Targetable signaling pathway mutations are associated with malignant phenotype in IDH-mutant gliomas
Hiroaki Wakimoto,Shota Tanaka,William T. Curry,Franziska Loebel,Dan Zhao,Kensuke Tateishi,Juxiang Chen,Lindsay K. Klofas,Nina Lelic,James Kim,Dora Dias-Santagata,Leif W. Ellisen,Darrell R. Borger,Sarah-Maria Fendt,Matthew G. Vander Heiden,Tracy T. Batchelor,A. John Iafrate,Daniel P. Cahill,Andrew S. Chi +18 more
TL;DR: A subset of IDH-mutant gliomas with mutations in driver oncogenes has a more malignant phenotype in patients, and identification of these alterations may provide an opportunity for use of targeted therapies in these patients.
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Intraneural ganglion cysts: a systematic review and reinterpretation of the world's literature
Nicholas M. Desy,Huan Wang,Mohanad Ahmed Ibrahim Elshiekh,Shota Tanaka,Tae Woong Choi,B. Matthew Howe,Robert J. Spinner +6 more
TL;DR: A comprehensive review of the world's literature on intraneural ganglion cysts and the MR images further supports the articular (synovial) theory and provides baseline data for future investigators.