J
James Lutterbaugh
Researcher at Case Western Reserve University
Publications - 35
Citations - 7128
James Lutterbaugh is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Colorectal cancer & DNA methylation. The author has an hindex of 27, co-authored 35 publications receiving 6838 citations. Previous affiliations of James Lutterbaugh include Howard Hughes Medical Institute & University Hospitals of Cleveland.
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Journal ArticleDOI
Inactivation of the Type II TGF-β Receptor in Colon Cancer Cells with Microsatellite Instability
Sanford D. Markowitz,Jing Wang,Lois Myeroff,Ramon Parsons,Lu Zhe Sun,James Lutterbaugh,Robert S. Fan,Elizabeth Zborowska,Kenneth W. Kinzler,Bert Vogelstein,Bert Vogelstein,Michael G. Brattain,James K V Willson +12 more
TL;DR: Human colon cancer cell lines with high rates of microsatellite instability were found to harbor mutations in the type II TGF-beta receptor (RII) gene, which links DNA repair defects with a specific pathway of tumor progression.
Journal ArticleDOI
Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers
Martina L. Veigl,Lakshmi Kasturi,Joseph Olechnowicz,Aihong Ma,James Lutterbaugh,Sumudra Periyasamy,Guo Min Li,James T. Drummond,Paul Modrich,W. David Sedwick,Sanford D. Markowitz +10 more
TL;DR: In this article, the absence of hMLH1 protein was associated with the methylation of the HMLH 1 gene promoter, which is intimately associated with this epigenetic silencing mechanism.
Journal Article
A Transforming Growth Factor β Receptor Type II Gene Mutation Common in Colon and Gastric but Rare in Endometrial Cancers with Microsatellite Instability
Lois Myeroff,Ramon Parsons,Seong-Jin Kim,Lora Hedrick,Kathleen R. Cho,Kim Orth,Michael Mathis,Kenneth W. Kinzler,James Lutterbaugh,Keunchil Park,Yung-Jue Bang,Hwa Young Lee,Jae-Gahb Park,Henry T. Lynch,Anita B. Roberts,Bert Vogelstein,Bert Vogelstein,Sanford D. Markowitz +17 more
TL;DR: The results suggest that RII gene mutations confer a growth advantage and are selected for in RER+ cancers of both the upper and lower gastrointestinal tract.
Journal Article
Mutational Inactivation of Transforming Growth Factor β Receptor Type II in Microsatellite Stable Colon Cancers
William M. Grady,Lois Myeroff,Sandra E. Swinler,Ashwani Rajput,Sam Thiagalingam,James Lutterbaugh,Aaron Neumann,Michael G. Brattain,Jay Chang,Seong Jin Kim,Ken W. Kinzler,Bert Vogelstein,James K V Willson,Sanford D. Markowitz +13 more
TL;DR: It is found that non-BAT-RII point mutations inactivate RII in another 15% of cases, thus doubling the known number of colon cancers in which RII mutations are pathogenetic.
Journal ArticleDOI
Detection in Fecal DNA of Colon Cancer–Specific Methylation of the Nonexpressed Vimentin Gene
Wei Dong Chen,Z. James Han,Joel Skoletsky,Jeff Olson,Jerome Frank Sah,Lois Myeroff,Petra Platzer,Shilong Lu,Dawn M. Dawson,Joseph Willis,Theresa P. Pretlow,James Lutterbaugh,Lakshmi Kasturi,James K V Willson,J. Sunil Rao,Anthony P. Shuber,Sanford D. Markowitz +16 more
TL;DR: Aberrant methylation of exon-1 sequences within the nontranscribed vimentin gene is a novel molecular biomarker of colon cancer and can be successfully detected in fecal DNA to identify nearly half of individuals with colon cancer.