K
Kathleen R. Cho
Researcher at University of Michigan
Publications - 174
Citations - 23081
Kathleen R. Cho is an academic researcher from University of Michigan. The author has contributed to research in topics: Ovarian cancer & Cancer. The author has an hindex of 72, co-authored 169 publications receiving 21341 citations. Previous affiliations of Kathleen R. Cho include Yale University & University of Florida.
Papers
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Journal ArticleDOI
Identification of a chromosome 18q gene that is altered in colorectal cancers
Eric R. Fearon,Kathleen R. Cho,Janice M. Nigro,Scott E. Kern,Jonathan W. Simons,J. Michael Ruppert,Stanley R. Hamilton,Antonette C. Preisinger,Giles Thomas,Kenneth W. Kinzler,Bert Vogelstein +10 more
TL;DR: A contiguous stretch of DNA comprising 370 kilobase pairs has now been cloned from a region of chromosome 18q suspected to reside near the DCC gene, which may play a role in the pathogenesis of human colorectal neoplasia, perhaps through alteration of the normal cell-cell interactions controlling growth.
Journal ArticleDOI
p53-Mediated Activation of miRNA34 Candidate Tumor-Suppressor Genes
Guido T. Bommer,Isabelle Gerin,Ying Feng,Andrew J. Kaczorowski,Rork Kuick,Robert E. Love,Yali Zhai,Thomas J. Giordano,Zhaohui S. Qin,Bethany B. Moore,Ormond A. MacDougald,Kathleen R. Cho,Eric R. Fearon +12 more
TL;DR: The data suggest the miRNA34s might be key effectors of p53 tumor-suppressor function, and their inactivation might contribute to certain cancers.
Journal ArticleDOI
Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy.
Dongjun Peng,Ilona Kryczek,Nisha Nagarsheth,Lili Zhao,Shuang Wei,Weimin Wang,Yuqing Sun,Ende Zhao,Linda Vatan,Wojciech Szeliga,Jan Kotarski,Rafał Tarkowski,Yali Dou,Kathleen R. Cho,Sharon Hensley-Alford,Adnan R. Munkarah,Rebecca Liu,Weiping Zou +17 more
TL;DR: Using human ovarian cancers as their model, this paper showed that enhancer of zeste homologue 2 (EZH2)-mediated histone H3 lysine 27 trimethylation (H3K27me3) and DNA methyltransferase 1 (DNMT1)-mediated DNA methylation repress the tumour production of T helper 1 (TH1)-type chemokines CXCL9 and CXCl10, and subsequently determine effector T-cell trafficking to the tumours microenvironment.
Journal Article
Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies.
Hironori Tashiro,Marian Blazes,Rong Wu,Kathleen R. Cho,Shikha Bose,Steven I. Wang,Jing Li,Ramon Parsons,Lora Hedrick Ellenson +8 more
TL;DR: The results support PTEN as a tumor suppressor gene and suggest that mutations in PTEN play a significant role in the pathogenesis of the endometrioid type of endometrial carcinoma.
Journal Article
DPC4 Gene in Various Tumor Types
Mieke Schutte,Ralph H. Hruban,Lora Hedrick,Kathleen R. Cho,Gyongyi Molnar Nadasdy,C. L. Weinstein,G. Steven Bova,William B. Isaacs,Paul Cairns,Homaira Nawroz,David Sidransky,Robert A. Casero,Paul S. Meltzer,Stephan A. Hahn,Scott E. Kern +14 more
TL;DR: The results indicate that whereas DPC4 inactivation is prevalent in pancreatic carcinoma (48%), it is distinctly uncommon in the other tumor types examined.