James M. Hyman

TL;DR: Cellular indicators of functional activity, including the immediate early genes (IEGs) zif268 (egr1), c-fos, and arc, in the prefrontal cortex of clinically depressed humans obtained postmortem and mice after chronic social defeat stress indicate that the activity of the mPFC is a key determinant of depression-like behavior, as well as antidepressant responses.

TL;DR: This is the first report of LTP being preferentially induced at the peak of local theTA rhythm in behaving animals in region CA1 and that LTD was found in response to tetanic stimulation at the trough of the local theta wave.

TL;DR: The majority of the mPFC cells with a significant correlation of firing rate changes with behavior were entrained to hippocampal theta, and cells that fired to specific events during only one direction of running were predisposed to theta modulation only in that direction.

TL;DR: Use of a DNMS task compared error trials vs. correct trials and found almost all mPFC cells fired at similar rates during both error and correct trials, however theta-entrainment of mP FC neurons declined during error performance as only 17% of cells were theTA-entrained (during correct trials 46% of the population was theta -entrained).

TL;DR: Using multiple single-unit tetrode recordings in rats, it is found that different activity patterns emerged in mPFC ensembles when animals moved between different environmental contexts, and it is suggested that themPFC forms rich contextual representations that take into account not only sensory cues but also actions and time.