Networks of coupled dynamical systems have been used to model biological oscillators, Josephson junction arrays, excitable media, neural networks, spatial games, genetic control networks and many other self-organizing systems. Ordinarily, the connection topology is assumed to be either completely regular or completely random. But many biological, technological and social networks lie somewhere between these two extremes. Here we explore simple models of networks that can be tuned through this middle ground: regular networks 'rewired' to introduce increasing amounts of disorder. We find that these systems can be highly clustered, like regular lattices, yet have small characteristic path lengths, like random graphs. We call them 'small-world' networks, by analogy with the small-world phenomenon (popularly known as six degrees of separation. The neural network of the worm Caenorhabditis elegans, the power grid of the western United States, and the collaboration graph of film actors are shown to be small-world networks. Models of dynamical systems with small-world coupling display enhanced signal-propagation speed, computational power, and synchronizability. In particular, infectious diseases spread more easily in small-world networks than in regular lattices.

/pdf/collective-dynamics-of-small-world-networks-205zhem3gm.pdf

Collective dynamics of small-world networks

There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality.

Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

I and i

抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

A 2.91-billion base pair (bp) consensus sequence of the euchromatic portion of the human genome was generated by the whole-genome shotgun sequencing method. The 14.8-billion bp DNA sequence was generated over 9 months from 27,271,853 high-quality sequence reads (5.11-fold coverage of the genome) from both ends of plasmid clones made from the DNA of five individuals. Two assembly strategies-a whole-genome assembly and a regional chromosome assembly-were used, each combining sequence data from Celera and the publicly funded genome effort. The public data were shredded into 550-bp segments to create a 2.9-fold coverage of those genome regions that had been sequenced, without including biases inherent in the cloning and assembly procedure used by the publicly funded group. This brought the effective coverage in the assemblies to eightfold, reducing the number and size of gaps in the final assembly over what would be obtained with 5.11-fold coverage. The two assembly strategies yielded very similar results that largely agree with independent mapping data. The assemblies effectively cover the euchromatic regions of the human chromosomes. More than 90% of the genome is in scaffold assemblies of 100,000 bp or more, and 25% of the genome is in scaffolds of 10 million bp or larger. Analysis of the genome sequence revealed 26,588 protein-encoding transcripts for which there was strong corroborating evidence and an additional approximately 12,000 computationally derived genes with mouse matches or other weak supporting evidence. Although gene-dense clusters are obvious, almost half the genes are dispersed in low G+C sequence separated by large tracts of apparently noncoding sequence. Only 1.1% of the genome is spanned by exons, whereas 24% is in introns, with 75% of the genome being intergenic DNA. Duplications of segmental blocks, ranging in size up to chromosomal lengths, are abundant throughout the genome and reveal a complex evolutionary history. Comparative genomic analysis indicates vertebrate expansions of genes associated with neuronal function, with tissue-specific developmental regulation, and with the hemostasis and immune systems. DNA sequence comparisons between the consensus sequence and publicly funded genome data provided locations of 2.1 million single-nucleotide polymorphisms (SNPs). A random pair of human haploid genomes differed at a rate of 1 bp per 1250 on average, but there was marked heterogeneity in the level of polymorphism across the genome. Less than 1% of all SNPs resulted in variation in proteins, but the task of determining which SNPs have functional consequences remains an open challenge.

http://science.sciencemag.org/content/sci/291/5507/1304.full.pdf

The sequence of the human genome.

Probability Distributions.- Linear Models for Regression.- Linear Models for Classification.- Neural Networks.- Kernel Methods.- Sparse Kernel Machines.- Graphical Models.- Mixture Models and EM.- Approximate Inference.- Sampling Methods.- Continuous Latent Variables.- Sequential Data.- Combining Models.

Pattern Recognition and Machine Learning

Author(s): Johnson, B. D.; Crutchfield, J. P.; Ellison, C. J.; McTague, C. S. | Abstract: We show how to efficiently enumerate a class of finite-memory stochastic processes using the causal representation of epsilon-machines. We characterize epsilon-machines in the language of automata theory and adapt a recent algorithm for generating accessible deterministic finite automata, pruning this over-large class down to that of epsilon-machines. As an application, we exactly enumerate topological epsilon-machines up to eight states and six-letter alphabets.

/pdf/enumerating-finitary-processes-4rldghk3av.pdf

Enumerating Finitary Processes

Current analyses of genomes from numerous species show that the diversity of organism's functional and behavioral characters is not proportional to the number of genes that encode the organism. We investigate the hypothesis that the diversity of organismal character is due to hierarchical organization. We do this with the recently introduced model of the finitary process soup, which allows for a detailed mathematical and quantitative analysis of the population dynamics of structural complexity. Here we show that global complexity in the finitary process soup is due to the emergence of successively higher levels of organization, that the hierarchical structure appears spontaneously, and that the process of structural innovation is facilitated by the discovery and maintenance of relatively noncomplex, but general individuals in a population.

Hierarchical Self-Organization in the Finitary Process Soup

We introduce the minimal maximally predictive models ({\epsilon}-machines) of
 processes generated by certain hidden semi-Markov models. Their causal states are either
 hybrid discrete-continuous or continuous random variables and causal-state transitions are
 described by partial differential equations. Closed-form expressions are given for
 statistical complexities, excess entropies, and differential information anatomy rates. We
 present a complete analysis of the {\epsilon}-machines of continuous-time renewal processes
 and, then, extend this to processes generated by unifilar hidden semi-Markov models and
 semi-Markov models. Our information-theoretic analysis leads to new expressions for the
 entropy rate and the rates of related information measures for these very general
 continuous-time process classes.

Informational and Causal Architecture of Continuous-time Renewal and Hidden Semi-Markov Processes

Current analyses of genomes from numerous species show that the diversity of their functional and behavioral characters is not proportional to the number of genes that encode the organism. We investigate the hypothesis that the diversity of organismal character is due to hierarchical organization. We do this with the recently introduced model of the finitary process soup, which allows for a detailed mathematical and quantitative analysis of the population dynamics of structural complexity. Here we show that global complexity in the finitary process soup is due to the emergence of successively higher levels of organization, that the hierarchical structure appears spontaneously, and that the process of structural innovation is facilitated by the discovery and maintenance of relatively noncomplex, but general, individuals in a population.

/pdf/hierarchical-self-organization-in-the-finitary-process-soup-2orwqyl9a2.pdf

Hierarchical self-organization in the finitary process soup

Among the predictive hidden Markov models that describe a given stochastic process, the $$\epsilon \text{-machine }$$
 is strongly minimal in that it minimizes every Renyi-based memory measure. Quantum models can be smaller still. In contrast with the $$\epsilon \text{-machine }$$
 ’s unique role in the classical setting, however, among the class of processes described by pure-state hidden quantum Markov models, there are those for which there does not exist any strongly minimal model. Quantum memory optimization then depends on which memory measure best matches a given problem’s circumstance.

/pdf/strong-and-weak-optimizations-in-classical-and-quantum-1we1tx0ai8.pdf

James P. Crutchfield

Papers

Enumerating Finitary Processes

Hierarchical Self-Organization in the Finitary Process Soup

Informational and Causal Architecture of Continuous-time Renewal and Hidden Semi-Markov Processes

Hierarchical self-organization in the finitary process soup

Strong and Weak Optimizations in Classical and Quantum Models of Stochastic Processes