J
James S. Molton
Researcher at National University of Singapore
Publications - 28
Citations - 1099
James S. Molton is an academic researcher from National University of Singapore. The author has contributed to research in topics: Liver abscess & Population. The author has an hindex of 11, co-authored 26 publications receiving 794 citations. Previous affiliations of James S. Molton include Royal Free London NHS Foundation Trust & University Health System.
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Journal ArticleDOI
The Global Spread of Healthcare-Associated Multidrug-Resistant Bacteria: a Perspective from Asia
James S. Molton,Paul A. Tambyah,Paul A. Tambyah,Brenda Ang,Moi Lin Ling,Dale Fisher,Dale Fisher +6 more
TL;DR: The authors in this article found that metallo-β-lactamase enzymes are encoded on highly transmissible plasmids that spread rapidly between bacteria, rather than relying on clonal proliferation.
The Global Spread of Healthcare-Associated Multidrug-Resistant Bacteria: A Perspective
Robert A. Weinstein,James S. Molton,Paul A. Tambyah,Brenda Ang,Moi Lin Ling,Dale Fisher,Yong Loo +6 more
TL;DR: As the antibiotic pipeline offers little in the short term, the most important tools against the spread of antibiotic resistant organisms are intensified infection control, surveillance and antimicrobial stewardship.
Journal ArticleDOI
Population genomics of hypervirulent Klebsiella pneumoniae clonal-group 23 reveals early emergence and rapid global dissemination
Margaret M. C. Lam,Kelly L. Wyres,Sebastián Duchêne,Ryan R. Wick,Louise M. Judd,Yunn-Hwen Gan,Chu Han Hoh,Sophia Archuleta,James S. Molton,Shirin Kalimuddin,Tse Hsien Koh,Virginie Passet,Sylvain Brisse,Kathryn E. Holt,Kathryn E. Holt +14 more
TL;DR: The authors investigate the genomic evolutionary history of CG23 and suggest a new reference strain for CG23, showing several deep-branching sublineages associated with distinct ICEKp acquisitions.
Journal ArticleDOI
Differential host susceptibility and bacterial virulence factors driving Klebsiella liver abscess in an ethnically diverse population
I. Russel Lee,James S. Molton,James S. Molton,Kelly L. Wyres,Claire L. Gorrie,Jocelyn Wong,Chu Han Hoh,Jeanette W. P. Teo,Shirin Kalimuddin,David C. Lye,David C. Lye,Sophia Archuleta,Sophia Archuleta,Kathryn E. Holt,Yunn-Hwen Gan +14 more
TL;DR: In this paper, the authors leveraged on the Antibiotics for Klebsiella Liver Abscess Syndrome Study (A-KLASS) clinical trial ongoing in ethnically diverse Singapore, to prospectively examine the profiles of 70 patients together with their isolates' genotypic and phenotypic characteristics.
Journal ArticleDOI
Remdesivir in Coronavirus Disease 2019 (COVID-19) treatment: a review of evidence.
Hui Xian Jaime Lin,Sanda Cho,Veeraraghavan Meyyur Aravamudan,Hnin Yu Sanda,Raj Palraj,James S. Molton,Indumathi Venkatachalam +6 more
TL;DR: In this article, the authors critically analyzed the evidence of remdesivir against COVID-19 and dissected the aspects over its safety and efficacy, based on existing data.