The present invention relates to substituted xanthines of general formula 
wherein R 1 to R 3 are as defined herein, the tautomers, the stereoisomers, the mixtures, the prodrugs thereof and the salts thereof which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).

8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions

An oral care agent delivery device is provided which comprises a permanently deformable backing layer, an oral care layer, and a non-woven binding material with a first part that is substantially invested in the oral care layer and a second part that is substantially invested in the backing layer. The device is sized to fit over a plurality of teeth in an upper or lower dental arch of a subject. The oral care layer comprises at least one oral care agent and at least one hydrophilic polymer. When hydrated, the oral care layer has an adhesiveness relative to the surface of a user's teeth that is sufficient to retain the device on the user's teeth when placed thereon. The device can also have an oral care agent which is activated on hydration of the oral care layer, or an oral care layer which releases the oral care agent over time.

Device and method for delivering an oral care agent

The specification describes the use of selected DPP IV inhibitors for the treatment of physiological functional disorders and for reducing the risk of the occurrence of such functional disorders in at-risk patient groups. In addition, the use of the above-mentioned DPP IV inhibitors in conjunction with other active substances is described, by means of which improved treatment outcomes can be achieved. These applications may be used to prepare corresponding medicaments.

Uses of DPP-IV inhibitors

The invention relates to the treatment or prevention of one or more conditions selected from type 1 diabetes mellitus, type 2 diabetes mellitus, impaired glucose tolerance and hyperglycemia using a SGLT-2 inhibitor. In addition the present invention relates to methods for preventing or treating of metabolic disorders and related conditions.

Pharmaceutical composition, methods for treating and uses thereof

The present invention provides apparatus and methods for completing a wellbore using expandable tubulars In one aspect, the invention includes a tubular member with an expandable portion at a lower end constructed and arranged to be expanded into contact with a previously expanded liner At an upper end of the tubular is a polish bore receptacle permitting the tubular to be tied back to the surface of the well with production tubing In another aspect, the invention provides a method of completing a well comprising expanding a liner top into a cased wellbore to hang the liner and, thereafter running a tubular member into the wellbore

Tie back and method for use with expandable tubulars

A dry film coating composition for use in coating pharmaceutical tablets, nutritional supplements, food, confectionery forms, agricultural seeds, and the like, comprises polyvinyl alcohol, a plasticizer such as polyethylene glycol or glycerin, talc, and preferably a pigment/opacifier and lecithin. A method of coating substrates such as pharmaceutical tablets, nutritional supplements, food, confectionery forms, agricultural seeds, and the like, with a film coating, comprises the steps of mixing polyvinyl alcohol, a plasticizer such as polyethylene glycol or glycerin, talc, and preferably a pigment/opacifier and lecithin into water to form an aqueous coating dispersion, applying an effective amount of said coating dispersion onto said substrates to form a film coating on said substrates, and drying the film coating on said substrates.

Film coatings and film coating compositions based on polyvinyl alcohol

This study investigates the influence of hybrid toughening—via core-shell rubber (CSR) particles and non-woven thermoplastic veils—on the delamination resistance, crack migration and R-curve behaviour in carbon fibre/epoxy laminates under mode-I and mode-II conditions. Core-shell rubber particles, varying in size from 100 nm to 3 μm, with 0–10 wt% content, are dispersed within the epoxy resin, and thermoplastic micro-fibre veils with polyphenylene sulfide (PPS) fibres, with 5–20 g/m2 areal weight, are introduced at the interlaminar region to achieve hybrid toughening. Carbon fibre/epoxy laminates are manufactured with a two-part resin using vacuum infusion and out-of-autoclave curing. Double cantilever beam (DCB) and four-point end-notch-flexure (4ENF) specimens are used to obtain mode-I and mode-II fracture energies and R-curves. Damage mechanisms and crack paths are characterised using fractography that provide understanding of energy dissipation. The results show that the hybrid toughening significantly improves fracture initiation and propagation energies (i.e. mode I initiation by ∼245% and propagation by ∼275%, and mode-II initiation by ∼64% and propagation ∼215%) by extrinsic and intrinsic toughening mechanisms. Moreover, it is shown that rising R-curves can be achieved with hybrid toughening when compared with falling R-curves obtained with just thermoplastic veil toughening. Fractography revealed that the hybrid toughening constrained the crack predominantly within the veil region, making it harder to grow and absorb more energy. 

On mode-I and mode-II interlaminar crack migration and R-curves in carbon/epoxy laminates with hybrid toughening via core-shell-rubber particles and thermoplastic micro-fibre veils

PROBLEM TO BE SOLVED: To provide a dry film coating composition for use in coating pharmaceutical tablets, nutritional supplements, food, confectionery forms, agricultural seeds, and analogs thereof.SOLUTION: The dry film coating composition comprises polyvinyl alcohol, a plasticizer such as polyethylene glycol or glycerin, talc, and preferably a pigment/opacifier and lecithin. A method of coating substrates such as the pharmaceutical tablets, the nutritional supplements, the food, the confectionery forms, the agricultural seeds, and the analogs thereof, with a film coating, comprises steps for: mixing the polyvinyl alcohol, the plasticizer such as the polyethylene glycol or the glycerin, the talc, and preferably the pigment/opacifier and the lecithin into water to form an aqueous coating dispersion; applying an effective amount of the coating dispersion onto the substrates to form a film coating on the substrates; and drying the film coating on the substrates.

Film coating and film coating composition based on polyvinyl alcohol

On the R-curve behaviour of carbon/epoxy laminates with core-shell rubber nanoparticle and micro-fibre veil hybrid toughening: Carbon vs PPS veils

The Effect of Hygrothermal Ageing on the Delamination of Carbon/epoxy Laminates with Core-shell Rubber Nanoparticle and Micro-fibre Thermoplastic Veil Toughening

James Taylor

Papers

Film coatings and film coating compositions based on polyvinyl alcohol

On mode-I and mode-II interlaminar crack migration and R-curves in carbon/epoxy laminates with hybrid toughening via core-shell-rubber particles and thermoplastic micro-fibre veils

Film coating and film coating composition based on polyvinyl alcohol

On the R-curve behaviour of carbon/epoxy laminates with core-shell rubber nanoparticle and micro-fibre veil hybrid toughening: Carbon vs PPS veils

The Effect of Hygrothermal Ageing on the Delamination of Carbon/epoxy Laminates with Core-shell Rubber Nanoparticle and Micro-fibre Thermoplastic Veil Toughening