J
James W. Whittaker
Researcher at Carnegie Mellon University
Publications - 23
Citations - 2587
James W. Whittaker is an academic researcher from Carnegie Mellon University. The author has contributed to research in topics: Galactose oxidase & Active site. The author has an hindex of 17, co-authored 23 publications receiving 2458 citations. Previous affiliations of James W. Whittaker include Oregon Health & Science University.
Papers
More filters
Book ChapterDOI
Active Site Ligand Interactions in Galactose Oxidase
TL;DR: X-ray crystallography now routinely reveals structures of metalloenzyme active sites at near atomic resolution, establishing the geometric features with unparalleled accuracy as discussed by the authors, but such data is still low resolution compared to the electronic level of detail that relates directly to the origins of chemical reactivity.
Journal ArticleDOI
Radical copper oxidases, one electron at a time
TL;DR: Isotope kinetics have been investigated for the substrate oxidation half-reaction indicating a dramatic isotope effect consistent with homolytic cleavage of the methylene C-H bond and hydrogen atom transfer to the phenoxyl in the transition state.
Journal ArticleDOI
Characterization of Mononuclear Copper-Nitrogen Oxide Complexes: Models of NOx Binding to Isolated Active Sites in Copper Proteins
William B. Tolman,Susan M. Carrier,Christy E. Ruggiero,William E. Antholine,James W. Whittaker +4 more
TL;DR: In this article, a detailed examination of the interactions of simple nitrogen oxides with metal ions has become increasingly important for understanding the role of NxOy n-species in numerous biochemically and environmentally significant processes.