Occurrence of 17α-ethynylestradiol (EE2) in the environment and effect on exposed biota: a review

Recent research has demonstrated the suitability of adult zebrafish to model some aspects of complex behaviour. Studies of reward behaviour, learning and memory, aggression, anxiety and sleep strongly suggest that conserved regulatory processes underlie behaviour in zebrafish and mammals. The isolation and molecular analysis of zebrafish behavioural mutants is now starting, allowing the identification of novel behavioural control genes. As a result of this, studies of adult zebrafish are now helping to uncover the genetic pathways and neural circuits that control vertebrate behaviour.

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Adult zebrafish as a model organism for behavioural genetics

https://hal.archives-ouvertes.fr/hal-00472008/document

Aromatase in the brain of teleost fish: expression, regulation and putative functions.

Recently, the importance of the female to population dynamics-especially her non-genetic contribution to offspring fitness or maternal effect-has received much attention in studies of a diverse collection of animal and plant taxa. Of particular interest to fisheries scientists and managers is the role of the demographic structure of the adult component of fish populations in the formation of future year classes. Traditionally, fisheries managers tended to assess whole populations without regard to variation between the individuals within the population. In doing so, they overlooked the variation in spawning production between individual females as a source of variation to recruitment magnitude and fluctuation. Indeed, intensive and/or selective harvesting of larger and older females, those that may produce more-and higher quality-offspring, has been implicated in the collapse of a number of important fish stocks. In a fisheries resource management context, whether capture fisheries or aquaculture, female demographics and inter-female differences warrant serious consideration in developing harvesting and breeding strategies, and in understanding general population dynamics. Here I review the range of female traits and environmental conditions females encounter which may influence the number or quality of their offspring via a maternal effect.

Maternal effects in fish populations.

Domoic acid and human exposure risks: A review

Effects of the synthetic estrogen, 17α-ethinylestradiol, on aggression and courtship behavior in male zebrafish (Danio rerio)

http://www-personal.umd.umich.edu/~mtwiner/PDFs/Coleman%20et%20al_Toxicon_2005.pdf

Teratogenic effects of azaspiracid-1 identified by microinjection of Japanese medaka (Oryzias latipes) embryos

Mapping and reconstruction of domoic acid-induced neurodegeneration in the mouse brain ☆

Brevetoxins are produced by the red tide dinoflagellate Karenia brevis. The toxins are lipophilic polyether toxins that elicit a myriad of effects depending on the route of exposure and the target organism. Brevetoxins are therefore broadly toxic to marine and estuarine animals. By mimicking the maternal route of exposure to the oocytes in finfish, we characterized the adverse effects of the type B brevetoxin brevetoxin-3 (PbTx-3) on embryonic fish development and survival. The Japanese rice fish, medaka (Oryzias latipes), was used as the experimental model in which individual eggs were exposed via microinjection to various known concentrations of PbTx-3 dissolved in an oil vehicle. Embryos injected with doses exceeding 1.0 ng/egg displayed tachycardia, hyperkinetic twitches in the form of sustained convulsions, spinal curvature, clumping of the erythrocytes, and decreased hatching success. Furthermore, fish dosed with toxin were often unable to hatch in the classic tail-first fashion and emerged head first, which resulted in partial hatches and death. We determined that the LD(50) (dose that is lethal to 50% of the fish) for an injected dose of PbTx-3 is 4.0 ng/egg. The results of this study complement previous studies of the developmental toxicity of the type A brevetoxin brevetoxin-1 (PbTx-1), by illustrating in vivo the differing affinities of the two congeners for cardiac sodium channels. Consequently, we observed differing cardiovascular responses in the embryos, wherein embryos exposed to PbTx-3 exhibited persistent tachycardia, whereas embryos exposed to PbTx-1 displayed bradycardia, the onset of which was delayed.

The type B brevetoxin (PbTx-3) adversely affects development, cardiovascular function, and survival in Medaka (Oryzias latipes) embryos.

Saffron cod (Eleginus gracilis) and Arctic cod (Boreogadus saida) are two circumpolar gadids that serve as critically important species responsible for energy transfer in Arctic food webs of the northern Bering and Chukchi Seas. To understand the potential effects of sea ice loss and warming temperatures on these species׳ basic life history, information such as growth is needed. Yet to date, limited effort has been dedicated to the study of their growth dynamics. Based on a large sample of otoliths collected in the first comprehensive ecosystem integrated survey in the northern Bering and Chukchi Seas, procedures were developed to reliably estimate age from otolith growth zones and were used to study the growth dynamics of saffron and Arctic cod. Annual growth zone assignment was validated using oxygen isotope signatures in otoliths and otolith morphology analyzed and compared between species. Saffron cod attained larger asymptotic sizes (L∞=363 mm) and achieved their maximum size at a faster rate (K=0.378) than Arctic cod (L∞=209 mm; K=0.312). For both species, regional differences in growth were found (p

Jamie R. Colman

Papers

Effects of the synthetic estrogen, 17α-ethinylestradiol, on aggression and courtship behavior in male zebrafish (Danio rerio)

Teratogenic effects of azaspiracid-1 identified by microinjection of Japanese medaka (Oryzias latipes) embryos

Mapping and reconstruction of domoic acid-induced neurodegeneration in the mouse brain ☆

The type B brevetoxin (PbTx-3) adversely affects development, cardiovascular function, and survival in Medaka (Oryzias latipes) embryos.

Growth dynamics of saffron cod (Eleginus gracilis) and Arctic cod (Boreogadus saida) in the Northern Bering and Chukchi Seas