J
Jan F. Richter
Researcher at Charité
Publications - 37
Citations - 4029
Jan F. Richter is an academic researcher from Charité. The author has contributed to research in topics: Tight junction & Barrier function. The author has an hindex of 22, co-authored 33 publications receiving 3580 citations. Previous affiliations of Jan F. Richter include University of Jena & Humboldt State University.
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Journal ArticleDOI
Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn’s disease
Sebastian Zeissig,Nataly Bürgel,Dorothee Günzel,Jan F. Richter,Joachim Mankertz,Ulrich Wahnschaffe,Anton J. Kroesen,Martin Zeitz,Michael Fromm,Joerg D. Schulzke +9 more
TL;DR: Upregulation of pore-forming claudin 2 and downregulation and redistribution of sealing claudins 5 and 8 lead to altered tight junction structure and pronounced barrier dysfunction already in mild to moderately active Crohn’s disease.
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Interleukin-13 Is the Key Effector Th2 Cytokine in Ulcerative Colitis That Affects Epithelial Tight Junctions, Apoptosis, and Cell Restitution
Frank Heller,Peter Florian,Christian Bojarski,Jan F. Richter,Melanie Christ,Bernd Hillenbrand,Joachim Mankertz,Alfred H. Gitter,Nataly Bürgel,Michael Fromm,Martin Zeitz,Ivan J. Fuss,Warren Strober,Jörg D. Schulzke +13 more
TL;DR: IL-13 was identified as an important effector cytokine in UC that impairs epithelial barrier function by affecting epithelial apoptosis, tight junctions, and restitution velocity.
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Epithelial Tight Junctions in Intestinal Inflammation
Joerg D. Schulzke,Svenja Ploeger,Maren Amasheh,Anja Fromm,Sebastian Zeissig,Hanno Troeger,Jan F. Richter,Christian Bojarski,Michael Schumann,Michael Fromm +9 more
TL;DR: Immune regulation of epithelial functions by cytokines may cause barrier dysfunction not only by tight junction impairments but also by apoptotic leaks, transcytotic mechanisms, and mucosal gross lesions.
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Tricellulin Forms a Barrier to Macromolecules in Tricellular Tight Junctions without Affecting Ion Permeability
Susanne M. Krug,Salah Amasheh,Jan F. Richter,Susanne Milatz,Dorothee Günzel,Julie K. Westphal,Julie K. Westphal,Otmar Huber,Otmar Huber,Jörg D. Schulzke,Michael Fromm +10 more
TL;DR: In conclusion, at low tricellulin expression the tTJ central tube forms a pathway for macromolecules and in bTJs for solutes of all sizes, and at higher expression, tricesllulin forms a barrier in tTJs effective only for Macromolecule and in tJ for solute of all size.
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Fermentable Fiber Ameliorates Fermentable Protein-Induced Changes in Microbial Ecology, but Not the Mucosal Response, in the Colon of Piglets
Robert Pieper,Susan Kröger,Jan F. Richter,Jing Wang,Lena Martin,Jérôme Bindelle,John K Htoo,Dorthe von Smolinski,Wilfried Vahjen,Jürgen Zentek,Andrew G. Van Kessel +10 more
TL;DR: F fermentable fiber ameliorates fermentable protein-induced changes in most measures of luminal microbial ecology but not the mucosal response in the large intestine of pigs.