J
Jan O. Friedrich
Researcher at University of Toronto
Publications - 180
Citations - 10524
Jan O. Friedrich is an academic researcher from University of Toronto. The author has contributed to research in topics: Randomized controlled trial & Renal replacement therapy. The author has an hindex of 48, co-authored 170 publications receiving 8864 citations. Previous affiliations of Jan O. Friedrich include Boston University & McMaster University.
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Journal ArticleDOI
Has mortality from acute respiratory distress syndrome decreased over time?: A systematic review.
Jason Phua,Joan Ramon Badia,Neill K. J. Adhikari,Jan O. Friedrich,Robert A. Fowler,Jeff Singh,Damon C. Scales,David R. Stather,Amanda Li,Andrew Jones,David Gattas,David Hallett,George Tomlinson,Thomas E. Stewart,Niall D. Ferguson +14 more
TL;DR: Mortality did not decrease between 1994 (when a consensus definition of ALI/ARDS was published) and 2006, and is lower in RCTs than observational studies.
Journal ArticleDOI
Prone ventilation reduces mortality in patients with acute respiratory failure and severe hypoxemia: systematic review and meta-analysis.
Sachin Sud,Jan O. Friedrich,Jan O. Friedrich,Paolo Taccone,Federico Polli,Neill K. J. Adhikari,Neill K. J. Adhikari,Roberto Latini,Antonio Pesenti,Claude Guérin,Jordi Mancebo,Martha A. Q. Curley,Rafael Fernandez,Ming Cheng Chan,Pascal Beuret,Gregor Voggenreiter,Maneesh Sud,Gianni Tognoni,Luciano Gattinoni +18 more
TL;DR: Prone ventilation reduces mortality in patients with severe hypoxemia and should not be routine in all patients with AHRF, but may be considered for severely hypoxemic patients.
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Meta-Analysis: Low-Dose Dopamine Increases Urine Output but Does Not Prevent Renal Dysfunction or Death
TL;DR: A systematic review and meta-analysis of low-dose dopamine was conducted by using a comprehensive search strategy to determine its effect on a broad range of clinical and renal physiologic outcomes and adverse events.
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Effect of nitric oxide on oxygenation and mortality in acute lung injury: systematic review and meta-analysis
Neill K. J. Adhikari,Karen E. A. Burns,Jan O. Friedrich,John Granton,Deborah J. Cook,Maureen O. Meade +5 more
TL;DR: Nitric oxide is associated with limited improvement in oxygenation in patients with ALI or ARDS but confers no mortality benefit and may cause harm.
Journal ArticleDOI
Inclusion of zero total event trials in meta-analyses maintains analytic consistency and incorporates all available data
TL;DR: To include all relevant data regardless of effect measure chosen, reviewers should also include zero total event trials when calculating pooled estimates using OR and RR.