Jan Olaf Stracke

TL;DR: The Brain Shuttle module is developed, which can be engineered into a standard therapeutic antibody for successful BBB transcytosis and provides in vitro and in vivo evidence that the monovalent binding mode facilitates transcellular transport, whereas a bivalent binding mode leads to lysosome sorting.

TL;DR: In this paper, the present invention relates to multispecific, especially bispecific antibodies comprising full length antibodies and single chain Fab fragments, methods for their production, pharmaceutical compositions containing the antibodies, and uses thereof.

TL;DR: Results demonstrate that FcRn affinity chromatography is a useful new method for the assessment of IgG integrity and correlates to changes in the PK profile in the F cRn transgenic mice.

TL;DR: The here presented approach greatly facilitates the evaluation of fermentation, purification, formulation, and storage conditions on antibody asparagine deamidation and aspartate isomerization by monitoring susceptible marker peptides located in the complementary-determining regions of recombinant antibodies.

TL;DR: Bispecific antibodies that bind cell-surface targets as well as digoxigenin (Dig) were generated for targeted payload delivery and complexes are targeted by the bispecifics to cancer cells and because these complexes are stable in serum, they can be applied for targeted delivery.