J
Jan Petz
Researcher at Mayo Clinic
Publications - 13
Citations - 1696
Jan Petz is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Primary sclerosing cholangitis & Ursodeoxycholic acid. The author has an hindex of 11, co-authored 13 publications receiving 1572 citations. Previous affiliations of Jan Petz include Arizona State University.
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Journal ArticleDOI
High Dose Ursodeoxycholic Acid for the Treatment of Primary Sclerosing Cholangitis
Keith D. Lindor,Kris V. Kowdley,Velimir A. Luketic,M. Edwyn Harrison,Timothy M. McCashland,Alex S. Befeler,Denise M. Harnois,Roberta A. Jorgensen,Jan Petz,Jill C. Keach,Jody Mooney,Carol Sargeant,Tamara Bernard,Debra King,Ellen Miceli,Jeff Schmoll,Tanya L. Hoskin,Prabin Thapa,Felicity Enders +18 more
TL;DR: Long‐term, high‐dose UDCA therapy is associated with improvement in serum liver tests in PSC but does not improve survival and was associated with higher rates of serious adverse events.
Journal ArticleDOI
Incidence and Risk Factors for Cholangiocarcinoma in Primary Sclerosing Cholangitis
TL;DR: Almost 7% of PSC patients later developed CCA over a mean follow-up of 11.5 yr, which is dramatically higher than the rates in the general population, and variceal bleeding is a major risk factor for the later development of CCA.
Journal ArticleDOI
High-Dose Ursodeoxycholic Acid Is Associated With the Development of Colorectal Neoplasia in Patients With Ulcerative Colitis and Primary Sclerosing Cholangitis
John E. Eaton,Marina G. Silveira,Darrell S. Pardi,Emmanouil Sinakos,Kris V. Kowdley,Velimir A. Luketic,M. Edwyn Harrison,Timothy M. McCashland,Alex S. Befeler,Denise M. Harnois,Roberta A. Jorgensen,Jan Petz,Keith D. Lindor +12 more
TL;DR: Patients who received high-dose UDCA had a significantly higher risk of developing colorectal neoplasia (dysplasia and cancer) during the study compared with those who received placebo.
Journal ArticleDOI
Does long-term home parenteral nutrition in adult patients cause chronic liver disease?
TL;DR: Persistent abnormalities of liver chemistries in nine patients and progressive liver disease while receiving home parenteral nutrition in three patients are quite worrisome and suggest that home p Arenteral Nutrition-associated steatohepatitis with or without cholestasis may progress to chronic liver disease.
Journal ArticleDOI
High dose ursodeoxycholic acid increases risk of adverse outcomes in patients with early stage primary sclerosing cholangitis
Mohamad Imam,Emmanouil Sinakos,Andrea A. Gossard,Kris V. Kowdley,Velimir A. Luketic,M. Edwyn Harrison,Timothy M. McCashland,Alex S. Befeler,Denise M. Harnois,Roberta A. Jorgensen,Jan Petz,Jill C. Keach,Alisha C. DeCook,Felicity Enders,Keith D. Lindor +14 more
TL;DR: Aliment Pharmacol Ther 2011; 34: 1185–1192.