J
Jan Slezak
Researcher at Slovak Academy of Sciences
Publications - 107
Citations - 1922
Jan Slezak is an academic researcher from Slovak Academy of Sciences. The author has contributed to research in topics: Ischemia & Sarcolemma. The author has an hindex of 21, co-authored 103 publications receiving 1577 citations. Previous affiliations of Jan Slezak include Slovak Medical University.
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Journal ArticleDOI
IL-10 attenuates TNF-α-induced NFκB pathway activation and cardiomyocyte apoptosis
Sanjiv Dhingra,Anita K. Sharma,Anita K. Sharma,Rakesh C. Arora,Rakesh C. Arora,Jan Slezak,Pawan K. Singal,Pawan K. Singal +7 more
TL;DR: The present study shows that TNF-alpha-induced activation of the NF kappaB pathway plays a critical role in cardiomyocyte apoptosis and inhibits IKK phosphorylation through the activation of ERK 1/2 MAPK.
Journal Article
Hydrogen peroxide changes in ischemic and reperfused heart. Cytochemistry and biochemical and X-ray microanalysis.
Jan Slezak,N. Tribulova,J. Pristacova,B. Uhrik,Thomas P. Thomas,Neelam Khaper,Nalini Kaul,Pawan K. Singal +7 more
TL;DR: A significant increase in myocardial H2O2 during both the phase of ischemia and the first few minutes of reperfusion supports a stronger reaction on the sarcolemma and abluminal side of endothelial cells as well as vulnerability of these sites to oxidative stress injury.
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Oxidative Stress-Responsive MicroRNAs in Heart Injury.
Branislav Kura,Barbara Szeiffova Bacova,Barbora Kalocayova,Matus Sykora,Matus Sykora,Jan Slezak +5 more
TL;DR: The need for studying the role of redox-sensitive miRNAs is pointed to to identify more effective biomarkers and develop better therapeutic targets for oxidative-stress-related heart diseases.
Journal ArticleDOI
Biology of TNFα and IL-10, and their imbalance in heart failure
Kuljeet Kaur,Sanjiv Dhingra,Sanjiv Dhingra,Jan Slezak,Anita K. Sharma,Anita K. Sharma,Anju Bajaj,Anju Bajaj,Pawan K. Singal,Pawan K. Singal +9 more
TL;DR: It is suggested that an optimal balance between IL-10 and TNFα may be a new therapeutic strategy for a healthier heart.
Journal ArticleDOI
A New Approach for the Prevention and Treatment of Cardiovascular Disorders. Molecular Hydrogen Significantly Reduces the Effects of Oxidative Stress
TL;DR: The mechanistic data, coupled with the pre-clinical and clinical studies, suggest that H2 may be useful for ROS/inflammation-induced cardiotoxicity and other conditions.