J
Jan Willem Thuring
Researcher at Janssen Pharmaceutica
Publications - 15
Citations - 410
Jan Willem Thuring is an academic researcher from Janssen Pharmaceutica. The author has contributed to research in topics: Protein arginine methyltransferase 5 & Chemistry. The author has an hindex of 5, co-authored 15 publications receiving 353 citations. Previous affiliations of Jan Willem Thuring include Johnson & Johnson Pharmaceutical Research and Development.
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Journal ArticleDOI
Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance.
Stephen Hare,Ann Vos,Reginald Clayton,Jan Willem Thuring,Maxwell D. Cummings,Peter Cherepanov +5 more
TL;DR: Improved resolution allowed us to refine the complete coordination spheres of the catalytic metal cations within the INSTI-bound intasome active site, and structures predict physical proximity and an interaction between HIV-1 IN mutant residues His148 and Ser/Ala140.
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Synthesis of 1-Boc-3-fluoroazetidine-3-carboxylic Acid
Eva Van Hende,Guido Verniest,Frederik Deroose,Jan Willem Thuring,Gregor James Macdonald,Norbert De Kimpe +5 more
TL;DR: Synthetic strategies toward 3-fluoroazetidine-3-carboxylic acid, a new cyclic fluorinated beta-amino acid with high potential as building block in medicinal chemistry, were evaluated.
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Discovery and Pharmacological Characterization of JNJ-64619178, a Novel Small Molecule Inhibitor of PRMT5 with Potent Anti-Tumor Activity.
Dirk Brehmer,Lijs Beke,Tongfei Wu,Hillary Millar,Christopher Moy,Weimei Sun,Geert Mannens,Vineet Pande,An Boeckx,Erika van Heerde,Thomas Nys,Emmanuel Gustin,Bie Verbist,Longen Zhou,Yue Fan,Vipul Bhargava,Pegah Safabakhsh,Petra Vinken,Tinne Verhulst,Angelique N Gilbert,Sumit Rai,Timothy A. Graubert,Friederike Pastore,Danilo Fiore,Junchen Gu,Amy J. Johnson,Ulrike Philippar,Barbara Morschhäuser,David Walker,Desiree De Lange,Vikki Keersmaekers,Viellevoye Marcel,Gaston Stanislas Marcella Diels,Wim Bert Griet Schepens,Jan Willem Thuring,Lieven Meerpoel,Kathryn Packman,Matthew V. Lorenzi,Sylvie Laquerre +38 more
TL;DR: In this paper, the authors describe the characterization of JNJ-64619178, a novel, selective, and potent protein arginine methyltransferase 5 (PRMT5) inhibitor, currently in clinical trials for patients with advanced solid tumors, non-Hodgkin's lymphoma, and lower risk myelodysplastic syndrome.
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Synthesis of 4-substituted 3,3-difluoropiperidines
Riccardo Surmont,Guido Verniest,Jan Willem Thuring,Gregor James Macdonald,Frederik Deroose,Norbert De Kimpe +5 more
TL;DR: This method was applied to establish the synthesis of N-protected 3,3-difluoroisonipecotic acid, a fluorinated gamma-amino acid with high potential as a building block in medicinal chemistry.
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Synthesis of 5-amino- and 5-hydroxy-3,3-difluoropiperidines
Riccardo Surmont,Guido Verniest,Jan Willem Thuring,Peter ten Holte,Frederik Deroose,Norbert De Kimpe +5 more
TL;DR: Synthetic routes toward new 5-amino- and 5-hydroxy-3,3-difluoropiperidines, which are of high interest as building blocks in medicinal chemistry, are described.