There is increasing evidence that genome-wide association ( GWA) studies represent a powerful approach to the identification of genes involved in common human diseases. We describe a joint GWA study ( using the Affymetrix GeneChip 500K Mapping Array Set) undertaken in the British population, which has examined similar to 2,000 individuals for each of 7 major diseases and a shared set of similar to 3,000 controls. Case-control comparisons identified 24 independent association signals at P < 5 X 10(-7): 1 in bipolar disorder, 1 in coronary artery disease, 9 in Crohn's disease, 3 in rheumatoid arthritis, 7 in type 1 diabetes and 3 in type 2 diabetes. On the basis of prior findings and replication studies thus-far completed, almost all of these signals reflect genuine susceptibility effects. We observed association at many previously identified loci, and found compelling evidence that some loci confer risk for more than one of the diseases studied. Across all diseases, we identified a large number of further signals ( including 58 loci with single-point P values between 10(-5) and 5 X 10(-7)) likely to yield additional susceptibility loci. The importance of appropriately large samples was confirmed by the modest effect sizes observed at most loci identified. This study thus represents a thorough validation of the GWA approach. It has also demonstrated that careful use of a shared control group represents a safe and effective approach to GWA analyses of multiple disease phenotypes; has generated a genome-wide genotype database for future studies of common diseases in the British population; and shown that, provided individuals with non-European ancestry are excluded, the extent of population stratification in the British population is generally modest. Our findings offer new avenues for exploring the pathophysiology of these important disorders. We anticipate that our data, results and software, which will be widely available to other investigators, will provide a powerful resource for human genetics research.

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Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

Erik Eriksen is a remarkable individual. He has no college degrees yet is Professor of Human Development at Harvard University. He came to psychology via art, which explains why the reader will find him painting contexts and backgrounds rather than stating dull facts and concepts. He has been a training psychoanalyst for many years as well as a perceptive observer of cultural and social settings and their effect on growing up. This is not just a book on childhood. It is a panorama of our society. Anxiety in young children, apathy in American Indians, confusion in veterans of war, and arrogance in young Nazis are scrutinized under the psychoanalytic magnifying glass. The material is well written and devoid of technical jargon. The theme of the volume is that it is human to have a long childhood which will leave a lifelong residue of emotional immaturity in man. Primitive groups and

Childhood and Society.

Recording of presentation introducing narrative analysis, outlining what it is, why it can be a useful approach, how to do it and where to find out more. Presentation given at methods@manchester seminar at University of Manchester on 4 March 2010.

What is Narrative Analysis

Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with lipid levels at P < 5 × 10(-8), including 62 loci not previously associated with lipid levels in humans. Using dense genotyping in individuals of European, East Asian, South Asian and African ancestry, we narrow association signals in 12 loci. We find that loci associated with blood lipid levels are often associated with cardiovascular and metabolic traits, including coronary artery disease, type 2 diabetes, blood pressure, waist-hip ratio and body mass index. Our results demonstrate the value of using genetic data from individuals of diverse ancestry and provide insights into the biological mechanisms regulating blood lipids to guide future genetic, biological and therapeutic research.

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Discovery and refinement of loci associated with lipid levels

Counseling psychologists face many approaches from which to choose when they conduct a qualitative research study. This article focuses on the processes of selecting, contrasting, and implementing five different qualitative approaches. Based on an extended example related to test interpretation by counselors, clients, and communities, this article provides a detailed discussion about five qualitative approaches— narrative research; case study research; grounded theory; phenomenology; and participatory action research—as alternative qualitative procedures useful in understanding test interpretation. For each approach, the authors offer perspectives about historical origins, definition, variants, and the procedures of research.

Qualitative Research Designs: Selection and Implementation

Narrative and Research in the Social Sciences Listening to People's Stories The Use of Narrative in Qualitative Interviews Interpreting People's Stories Narrative Approaches to the Analysis of Qualitative Data Collecting Quantitative Narratives - A Contradiction in Terms? Statistical Stories? The Use of Narrative in Quantitative Analysis Uncovering and Understanding Causal Effects and Processes Narrative and Identity Constructions of the Subject in Qualitative and Quantitative Research The Ethical and Political Implications of Using Narrative in Research The Researcher as Narrator Reflexivity in Qualitative and Quantitative Research Telling Better Stories? Combining Qualitative and Quantitative Research

Using narrative in social research: qualitative and quantitative approaches

The 1958 birth cohort or the National Child Development Study (NCDS) began as a study of Perinatal Mortality focussing on just over 17 000 births in a single week in 1958. To address concerns regarding the stillbirth rate not falling, the original study aimed to identify social and obstetric factors linked to stillbirth and neonatal death. The findings contributed to the improvement of maternity services in Britain and to a reduction in perinatal mortality. 1 The initial survey was not planned as a longitudinal study, but subsequently the National Children’s Bureau was commissioned by the Central Advisory Council for Education (The Plowden Committee) to retrace the cohort at age 7 and monitor their educational, physical, and social development. 2

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Cohort profile: 1958 British birth cohort (National Child Development Study)

a summary of the subject of the narrative); the orientation (time, place, situation, participants); the complicating action (what actually happened); the evaluation (the meaning and significance of the action); the resolution (what finally happened); and lastly the coda, which returns the perspective to the present. Labov and Waletzky (1997) argued that these structures are typically used by the teller to construct a story out of past experiences, and to make sense of those experiences both for himor herself and for the audience.Although not all narratives necessarily include all of these six elements, at a minimum a narrative must include the complicating action, i.e. a temporal component, while it is the evaluation that has been highlighted as crucial for establishing the point or the meaning of the story. A number of authors have argued that the evaluation is socially the most important component of the narrative (Linde, 1993; Polanyi, 1985). In a conversational setting, for example, the narrator must guard against the ‘so what?’ response to a story. This is accomplished by providing an adequate evaluation of the events that have been recounted (Polanyi, 1985). It is the evaluation that conveys to an audience how they are to understand the meaning of the events that constitute the narrative, and simultaneously indicates what type of response is required.The evaluation should not therefore be understood as simply provided by the narrator; rather the achievement of agreement on the evaluation of a narrative is the product of a process of negotiation. While the speaker can be understood as responsible for producing a narrative with an acceptable evaluation, the addressee or audience must collaborate by demonstrating that the evaluation has been understood. Labov and Waletzky (1997) have suggested that the evaluation is typically placed between the complicating action and the resolution, and in this position creates an element of tension and suspense in a well-formed narrative, as the audience wait to hear ‘what happened next’. However, subsequent writers have underlined that the structural analysis of narrative provided by Labov and Waletzky is in many respects too rigid. The evaluation may in some cases be explicit, and may be located prior to the resolution, but the expression of the evaluation within a narrative need not take this form. A narrator may communicate evaluative elements more implicitly.As Tannen (1980) has argued, not only do narratives make explicit evaluations of actions and characters but judgements can be communicated in more subtle ways as well. She suggested that lexical choice (i.e. the use of specific words) within the other components of the narrative is a clear example of this type of implicit evaluation. In addition, it could be argued that the very telling of a narrative represents an evaluative act. It suggests that certain events and decisions are reportable by virtue of their significance or their unusual or unexpected qualities. Obvious examples here would be stories about the death of a parent, or the birth of a child.Within modern culture, these events are understood to have an emotional significance for the individual that makes them worthy of recounting.Alternatively many conversational stories are centred upon a coincidence, which while relatively trivial is seen as sufficiently unexpected to make it interesting to relate. NARRATIVE AND NEW DEVELOPMENTS IN THE SOCIAL SCIENCES 9 Elliot-01.qxd 4/8/2005 11:57 AM Page 9

Using Narrative in Social Research

The 1970 British Birth Cohort Study (BCS70) is an ongoing, multidisciplinary, longitudinal study. It takes as its subjects all those currently living in England, Scotland, and Wales who were born in a single week of 1970. To date there have been seven sweeps of the study, including the original birth survey. BCS70 began as the British Births Survey, when data was collected about the births and social circumstances of over 17 000 babies born in England, Scotland, Wales, and Northern Ireland. Data were collected using a questionnaire completed by the midwife who had been present at the birth and, in addition, information was extracted from clinical records. The original study was sponsored by the National Birthday Trust Fund in collaboration with the Royal College of Obstetricians and Gynaecologists, under the directorship of Roma and Geoffrey Chamberlain. The study aimed to examine the social and biological characteristics of the mother in relation to neonatal morbidity, and to compare the results with those of the 1958 National Child Development Study. When the cohort children were 3.5 yr the study transferred to the Department of Child Health at the University of Bristol where Neville Butler, Professor of Child Health, took over responsibility for the follow-ups at 5 and 10 yr, what came to be known as the Child Health and Education Study. In 1975 and 1980, parents of the children in the study were interviewed by health visitors, and information was gathered from the child’s class teacher and head teacher, from the school health service, and from the children themselves. Cohort members who were born in Northern Ireland were included in the birth survey but dropped from the study in all subsequent sweeps. The main findings on health from the 5 and 10 yr surveys are published in a report by the original team. 1

Cohort profile: 1970 British Birth Cohort (BCS70).

https://www.pure.ed.ac.uk/ws/files/21656497/1_s2.0_S0277953614001312_main.pdf

Jane Elliott

Papers

Using narrative in social research: qualitative and quantitative approaches

Cohort profile: 1958 British birth cohort (National Child Development Study)

Using Narrative in Social Research

Cohort profile: 1970 British Birth Cohort (BCS70).

Neighbourhood cohesion and mental wellbeing among older adults: A mixed methods approach