J
Janet A. Gilbertson
Researcher at University College London
Publications - 121
Citations - 6261
Janet A. Gilbertson is an academic researcher from University College London. The author has contributed to research in topics: Amyloidosis & Transthyretin. The author has an hindex of 31, co-authored 104 publications receiving 4879 citations. Previous affiliations of Janet A. Gilbertson include St Bartholomew's Hospital & Royal Free Hospital.
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Journal ArticleDOI
Natural history and outcome in systemic AA amyloidosis.
Helen J. Lachmann,Hugh J. B. Goodman,Janet A. Gilbertson,J. Ruth Gallimore,Caroline A. Sabin,Julian D. Gillmore,Philip N. Hawkins +6 more
TL;DR: The effects of renal dysfunction dominate the course of AA amyloidosis, which is associated with a relatively favorable outcome in patients with SAA concentrations that remain in the low-normal range (<4 mg per liter).
Journal ArticleDOI
Misdiagnosis of hereditary amyloidosis as AL (primary) amyloidosis.
Helen J. Lachmann,David R. Booth,SE Booth,A Bybee,Janet A. Gilbertson,Julian D. Gillmore,Mark B. Pepys,Philip N. Hawkins +7 more
TL;DR: A genetic cause should be sought in all patients with amyloidsosis that is not the reactive systemic amyloid A type and in whom confirmation of the light-chain (AL) type cannot be obtained.
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A new staging system for cardiac transthyretin amyloidosis
Julian D. Gillmore,Thibaud Damy,Marianna Fontana,Matthew Hutchinson,Helen J. Lachmann,Ana Martinez-Naharro,Candida Cristina Quarta,Tamer Rezk,Carol J. Whelan,Esther Gonzalez-Lopez,Thirusha Lane,Janet A. Gilbertson,Dorota Rowczenio,Aviva Petrie,Philip N. Hawkins +14 more
TL;DR: This simple, universally applicable staging system stratifies patients with both ATTRwt and ATTRv amyloid cardiomyopathy into prognostic categories will be of value in the design of forthcoming clinical trials of novel amyloids-specific therapies.
Journal ArticleDOI
Native T1 mapping in transthyretin amyloidosis
Marianna Fontana,Sanjay M Banypersad,Thomas A. Treibel,Viviana Maestrini,Daniel Sado,Steven K White,Silvia Pica,Silvia Castelletti,Stefan K. Piechnik,Matthew D. Robson,Janet A. Gilbertson,Dorota Rowczenio,David F. Hutt,Helen J. Lachmann,Ashutosh D. Wechalekar,Carol J. Whelan,Julian D. Gillmore,Philip N. Hawkins,James C. Moon +18 more
TL;DR: Native myocardial T1 mapping detects cardiac ATTR amyloid with similar diagnostic performance and disease tracking to AL amyloids, but with lower maximal T1 elevation, and appears to be an early disease marker.
Journal ArticleDOI
Antibodies to human serum amyloid P component eliminate visceral amyloid deposits
Karl Bodin,Stephan Ellmerich,Melvyn C. Kahan,Glenys A. Tennent,Andrzej Loesch,Janet A. Gilbertson,Winston L. Hutchinson,Palma Mangione,Palma Mangione,J. Ruth Gallimore,David J. Millar,Shane Minogue,Amar P. Dhillon,Graham W. Taylor,Arthur R. Bradwell,Aviva Petrie,Julian D. Gillmore,Vittorio Bellotti,Vittorio Bellotti,Marina Botto,Philip N. Hawkins,Mark B. Pepys +21 more
TL;DR: It is shown that administration of anti-human-SAP antibodies to mice with amyloid deposits containing human SAP triggers a potent, complement-dependent, macrophage-derived giant cell reaction that swiftly removes massive visceral amyloids deposits without adverse effects.