J
Janet M. Shaw
Researcher at University of Utah
Publications - 86
Citations - 8231
Janet M. Shaw is an academic researcher from University of Utah. The author has contributed to research in topics: Mitochondrion & Mitochondrial fission. The author has an hindex of 40, co-authored 83 publications receiving 7686 citations. Previous affiliations of Janet M. Shaw include University of California, Los Angeles.
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Journal ArticleDOI
The dynamin-related GTPase Dnm1 regulates mitochondrial fission in yeast
William Bleazard,J. Michael McCaffery,Edward J. King,Susan Bale,Amy D. Mozdy,Quinton Tieu,Jodi Nunnari,Janet M. Shaw +7 more
TL;DR: Dnm1 regulates mitochondrial fission, assembling on the cytoplasmic face of mitochondrial tubules at sites at which division will occur, and preventing mitochondrial fragmentation in fzo1 mutant strains.
Journal ArticleDOI
Mitochondrial morphology and dynamics in yeast and multicellular eukaryotes.
Koji Okamoto,Janet M. Shaw +1 more
TL;DR: Recent advances in the field of mitochondrial dynamics are reviewed and the importance of these pathways to human health is highlighted.
Journal ArticleDOI
Dnm1p Gtpase-Mediated Mitochondrial Fission Is a Multi-Step Process Requiring the Novel Integral Membrane Component Fis1p
TL;DR: It is proposed that mitochondrial fission in yeast is a multi-step process, and that membrane-bound Fis1p is required for the proper assembly, membrane distribution, and function of Dnm1p-containing complexes during fission.
Journal ArticleDOI
Mitochondrial fusion in yeast requires the transmembrane GTPase Fzo1p
Greg J. Hermann,John Thatcher,John P. Mills,Karen G. Hales,Margaret T. Fuller,Jodi Nunnari,Janet M. Shaw +6 more
TL;DR: It is proposed that the fuzzy onions family of transmembrane GTPases act as molecular switches to regulate a key step in mitochondrial membrane docking and/or fusion.
Journal ArticleDOI
The Dynamin-related GTPase, Dnm1p, Controls Mitochondrial Morphology in Yeast
Denichiro Otsuga,Brian R. Keegan,Ellen Brisch,John Thatcher,Greg J. Hermann,William Bleazard,Janet M. Shaw +6 more
TL;DR: It is demonstrated that Dnm1p is required for the cortical distribution of the mitochondrial network in yeast, a novel function for a dynamin-related protein.