Janet R. Nicholson

TL;DR: Burrowing behavior provides an objective, non-reflexive read-out for pain-related behavior in the MIA model that has predictive validity in detecting analgesic efficacy of nonsteroidal anti-inflammatory drugs (NSAIDs) and an anti-NGF mAb.

TL;DR: It is demonstrated that mGluR5 allosteric modulation selectively dissociates motor and choice impulsivity and may have therapeutic utility in selectively targeting specific aspects of impulsiveness and executive dysfunction.

TL;DR: The data collectively show that burrowing behavior is altered in rodent models of chronic inflammatory pain and peripheral neuropathic pain, however, large group sizes are needed to ensure studies are adequately powered due to considerable inter-animal variability.

TL;DR: It is found that D1R and D2R modulate different stages of reversal learning through effects localised to different sub-regions of the striatum, indicating that deficits in behavioral flexibility observed in disorders linked to dopamine perturbations may be attributable to specific D1 R and D 2R dysfunction in distinct striatal sub-Regions.

TL;DR: J-2156 mediated pain relief in BCIBP-rats was confirmed by observations of a reduction in the levels of phosphorylated extracellular signal-regulated kinase (pERK), a protein essential for central sensitization and persistent pain, in the spinal dorsal horn.