J
Jeffrey W. Dalley
Researcher at University of Cambridge
Publications - 219
Citations - 24288
Jeffrey W. Dalley is an academic researcher from University of Cambridge. The author has contributed to research in topics: Impulsivity & Nucleus accumbens. The author has an hindex of 73, co-authored 200 publications receiving 22183 citations. Previous affiliations of Jeffrey W. Dalley include University College London & École Polytechnique Fédérale de Lausanne.
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Impulsivity, compulsivity, and top-down cognitive control.
TL;DR: The results indicate that the vulnerability to stimulant addiction may depend on an impulsivity endophenotype, and characterize in neurobehavioral and neurochemical terms a rodent model of impulsivity based on premature responding in an attentional task.
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Prefrontal executive and cognitive functions in rodents: neural and neurochemical substrates
TL;DR: It is anticipated that a greater understanding of the prefrontal cortex will come from using tasks that load specific cognitive and executive processes, in parallel with discovering new ways of manipulating the different sub-regions and neuromodulatory systems of the cortex.
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Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement.
Jeffrey W. Dalley,Tim D. Fryer,Laurent Brichard,Emma S J Robinson,David E. H. Theobald,Kristjan Lääne,Yolanda Pena,Emily R. Murphy,Yasmene B. Shah,Katrin C. Probst,Irina Abakumova,Franklin I. Aigbirhio,Hugh K. Richards,Young T. Hong,Jean-Claude Baron,Barry J. Everitt,Trevor W. Robbins +16 more
TL;DR: It is reported that a form of impulsivity in rats predicts high rates of intravenous cocaine self-administration and is associated with changes in dopamine function before drug exposure, and that D2 receptor dysfunction in abstinent cocaine addicts may, in part, be determined by premorbid influences.
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High Impulsivity Predicts the Switch to Compulsive Cocaine-Taking
TL;DR: Experimental evidence is shown that a shift from impulsivity to compulsivity occurs during the development of addictive behavior, which provides insights into the genesis and neural mechanisms of drug addiction.
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Neural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addiction
Barry J. Everitt,David Belin,Daina Economidou,Yann Pelloux,Jeffrey W. Dalley,Trevor W. Robbins +5 more
TL;DR: Evidence showing that impulsivity, a spontaneously occurring behavioural tendency in outbred rats that is associated with low dopamine D2/3 receptors in the nucleus accumbens, predicts both the propensity to escalate cocaine intake and the switch to compulsive drug seeking and addiction is summarized.