J
Janice Gerloff
Researcher at University of Rochester Medical Center
Publications - 15
Citations - 1511
Janice Gerloff is an academic researcher from University of Rochester Medical Center. The author has contributed to research in topics: COPD & Oxidative stress. The author has an hindex of 15, co-authored 15 publications receiving 1172 citations. Previous affiliations of Janice Gerloff include University of Rochester.
Papers
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Journal ArticleDOI
Vapors Produced by Electronic Cigarettes and E-Juices with Flavorings Induce Toxicity, Oxidative Stress, and Inflammatory Response in Lung Epithelial Cells and in Mouse Lung
Chad A. Lerner,Isaac K. Sundar,Hongwei Yao,Janice Gerloff,Deborah J. Ossip,Scott McIntosh,Risa J. Robinson,Irfan Rahman +7 more
TL;DR: Exposure to e-cig aerosols/juices incurs measurable oxidative and inflammatory responses in lung cells and tissues that could lead to unrealized health consequences.
Journal ArticleDOI
Impaired mitophagy leads to cigarette smoke stress-induced cellular senescence: Implications for chronic obstructive pulmonary disease
Tanveer Ahmad,Isaac K. Sundar,Chad A. Lerner,Janice Gerloff,Ana M. Tormos,Hongwei Yao,Irfan Rahman +6 more
TL;DR: Mitochondria‐targeted antioxidant (Mito‐Tempo) restored impaired mitophagy, decreased mitochondrial mass accumulation, and delayed cellular senescence in Parkin‐overexpressing cells, which provides a promising therapeutic intervention in chronic airway diseases.
Journal ArticleDOI
Inflammatory and oxidative responses induced by exposure to commonly used e-cigarette flavoring chemicals and flavored e-liquids without nicotine
Thivanka Muthumalage,Melanie Prinz,Kwadwo O. Ansah,Janice Gerloff,Isaac K. Sundar,Irfan Rahman +5 more
TL;DR: The data suggest that the flavorings used in e-juices can trigger an inflammatory response in monocytes, mediated by ROS production, providing insights into potential pulmonary toxicity and tissue damage in e.cigarette users.
Journal ArticleDOI
Inflammatory Response and Barrier Dysfunction by Different e-Cigarette Flavoring Chemicals Identified by Gas Chromatography-Mass Spectrometry in e-Liquids and e-Vapors on Human Lung Epithelial Cells and Fibroblasts.
Janice Gerloff,Isaac K. Sundar,Robert Freter,Emily R. Sekera,Alan E. Friedman,Risa Robinson,Todd Pagano,Irfan Rahman +7 more
TL;DR: It is suggested that some of the e-cig liquids/aerosols containing flavoring chemicals can cause significant loss of epithelial barrier function and proinflammatory response in lung cells.
Journal ArticleDOI
SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism
Hongwei Yao,Isaac K. Sundar,Tanveer Ahmad,Chad A. Lerner,Janice Gerloff,Alan E. Friedman,Richard P. Phipps,Patricia J. Sime,Michael W. McBurney,Leonard Guarente,Irfan Rahman +10 more
TL;DR: Findings reveal a novel function of SIRT1, which is to reduce CS-induced oxidative stress, and this may contribute to its protective effects against lung inflammation and subsequent development of COPD.