J
Jared M. Cregg
Researcher at Case Western Reserve University
Publications - 21
Citations - 2088
Jared M. Cregg is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Regeneration (biology) & Spinal cord injury. The author has an hindex of 13, co-authored 19 publications receiving 1722 citations. Previous affiliations of Jared M. Cregg include University of Copenhagen & Michigan Technological University.
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Journal ArticleDOI
Functional regeneration beyond the glial scar.
Jared M. Cregg,Marc A. DePaul,Angela R. Filous,Bradley T. Lang,Amanda Phuong Tran,Jerry Silver +5 more
TL;DR: Evidence that this aggregate scar acts as the major barrier to regeneration of axons after injury is reviewed and several exciting new interventions that allow axons to regenerate beyond the glial scar are considered.
Journal ArticleDOI
Modulation of the proteoglycan receptor PTPσ promotes recovery after spinal cord injury
Bradley T. Lang,Jared M. Cregg,Marc A. DePaul,Amanda Phuong Tran,Kui Xu,Scott M. Dyck,Kathryn M. Madalena,Benjamin P. Brown,Yi Lan Weng,Shuxin Li,Soheila Karimi-Abdolrezaee,Sarah A. Busch,Yingjie Shen,Jerry Silver +13 more
TL;DR: Systemic delivery of this peptide over weeks restored substantial serotonergic innervation to the spinal cord below the level of injury and facilitated functional recovery of both locomotor and urinary systems.
Journal ArticleDOI
Creation of highly aligned electrospun poly-L-lactic acid fibers for nerve regeneration applications.
Han Bing Wang,Michael E. Mullins,Jared M. Cregg,Andres Hurtado,Andres Hurtado,Martin Oudega,Martin Oudega,Matthew T. Trombley,Ryan J. Gilbert +8 more
TL;DR: Together, this work presents methods by which to produce highly aligned fiber scaffolds efficiently and techniques for assessing neurite outgrowth on different Fiber scaffolds, while suggesting that crossing fibers may be detrimental in fostering efficient, directed axonal outgrowth.
Journal ArticleDOI
Varying the diameter of aligned electrospun fibers alters neurite outgrowth and Schwann cell migration.
TL;DR: Fiber diameter is an important parameter to consider when constructing aligned, electrospun fibers for nerve regeneration applications because in some situations, topography alone is sufficient to guide neurites without the leading support of SCs.
Journal ArticleDOI
Robust CNS regeneration after complete spinal cord transection using aligned poly-L-lactic acid microfibers.
Andres Hurtado,Jared M. Cregg,Jared M. Cregg,Han Bing Wang,Dane F. Wendell,Martin Oudega,Ryan J. Gilbert,John W. McDonald,John W. McDonald +8 more
TL;DR: It is reported that aligned microfiber-based grafts foster robust regeneration of vascularized CNS tissue and outline a form of regeneration within the central nervous system that holds important implications for regeneration biology.