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Yi Lan Weng
Researcher at Houston Methodist Hospital
Publications - 20
Citations - 1475
Yi Lan Weng is an academic researcher from Houston Methodist Hospital. The author has contributed to research in topics: Axon & Regeneration (biology). The author has an hindex of 11, co-authored 16 publications receiving 1010 citations. Previous affiliations of Yi Lan Weng include Case Western Reserve University & National Yang-Ming University.
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Journal ArticleDOI
Modulation of the proteoglycan receptor PTPσ promotes recovery after spinal cord injury
Bradley T. Lang,Jared M. Cregg,Marc A. DePaul,Amanda Phuong Tran,Kui Xu,Scott M. Dyck,Kathryn M. Madalena,Benjamin P. Brown,Yi Lan Weng,Shuxin Li,Soheila Karimi-Abdolrezaee,Sarah A. Busch,Yingjie Shen,Jerry Silver +13 more
TL;DR: Systemic delivery of this peptide over weeks restored substantial serotonergic innervation to the spinal cord below the level of injury and facilitated functional recovery of both locomotor and urinary systems.
Journal ArticleDOI
m 6 A facilitates hippocampus-dependent learning and memory through YTHDF1
Hailing Shi,Xuliang Zhang,Xuliang Zhang,Yi Lan Weng,Zongyang Lu,Yajing Liu,Zhike Lu,Jianan Li,Piliang Hao,Yu Zhang,Feng Zhang,You Wu,Jary Y. Delgado,Yijing Su,Meera J. Patel,Xiaohua Cao,Bin Shen,Xingxu Huang,Guo Li Ming,Xiaoxi Zhuang,Hongjun Song,Chuan He,Tao Zhou +22 more
TL;DR: It is shown that, through its binding protein YTHDF1, m6A promotes protein translation of target transcripts in response to neuronal stimuli in the adult mouse hippocampus, thereby facilitating learning and memory.
Journal ArticleDOI
Epitranscriptomic m6A Regulation of Axon Regeneration in the Adult Mammalian Nervous System.
Yi Lan Weng,Yi Lan Weng,Xu Wang,Ran An,Jessica Cassin,Caroline Vissers,Yuanyuan Liu,Yajing Liu,Tianlei Xu,Xinyuan Wang,Samuel Zheng Hao Wong,Jessica Joseph,Louis C. Dore,Qiang Dong,Wei Zheng,Peng Jin,Hao Wu,Bin Shen,Xiaoxi Zhuang,Chuan He,Kai Liu,Hongjun Song,Guo Li Ming +22 more
TL;DR: It is reported that sciatic nerve lesion elevates levels of m6A-tagged transcripts encoding many regeneration-associated genes and protein translation machinery components in the adult mouse dorsal root ganglion (DRG).
Journal ArticleDOI
Tet3 regulates synaptic transmission and homeostatic plasticity via DNA oxidation and repair.
Huimei Yu,Yijing Su,Jaehoon Shin,Chun Zhong,Junjie U. Guo,Yi Lan Weng,Fuying Gao,Daniel H. Geschwind,Giovanni Coppola,Guo Li Ming,Hongjun Song +10 more
TL;DR: It is found that synaptic activity bi-directionally regulates neuronal Tet3 expression and serves as a synaptic activity sensor to epigenetically regulate fundamental properties and meta-plasticity of neurons via active DNA demethylation.
Journal ArticleDOI
An Intrinsic Epigenetic Barrier for Functional Axon Regeneration.
Yi Lan Weng,Ran An,Ran An,Jessica Cassin,Jessica Joseph,Ruifa Mi,Chen Wang,Chun Zhong,Seung Gi Jin,Gerd P. Pfeifer,Alfonso Bellacosa,Xinzhong Dong,Ahmet Hoke,Zhigang He,Hongjun Song,Guo Li Ming +15 more
TL;DR: This study shows that peripheral sciatic nerve lesion in adult mice leads to elevated levels of Tet3 and 5-hydroxylmethylcytosine in dorsal root ganglion neurons, and suggests an epigenetic barrier that can be removed by active DNA demethylation to permit axon regeneration in the adult mammalian nervous system.