J
Jarmo Körkkö
Researcher at Allegheny University of the Health Sciences
Publications - 3
Citations - 270
Jarmo Körkkö is an academic researcher from Allegheny University of the Health Sciences. The author has contributed to research in topics: Gene & Gel electrophoresis. The author has an hindex of 3, co-authored 3 publications receiving 266 citations.
Papers
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Journal ArticleDOI
Conformation sensitive gel electrophoresis for simple and accurate detection of mutations: Comparison with denaturing gradient gel electrophoresis and nucleotide sequencing
TL;DR: In a survey of 736 alleles of collagen genes, CSGE detected 223 unique single-base mismatches that were confirmed by nucleotide sequencing and has the advantage over other methods for scanning PCR products in that it is simple, requires no special preparation of PCR products, has a large capacity, and does not use radioactivity.
Journal ArticleDOI
Procollagen with Skipping of α1(I) Exon 41 Has Lower Binding Affinity for α1(I) C-telopeptide, Impaired in Vitro Fibrillogenesis, and Altered Fibril Morphology
Wayne A. Cabral,Andrzej Fertala,Laura K. Green,Jarmo Körkkö,Antonella Forlino,Joan C. Marini +5 more
TL;DR: The results suggest that some collagen molecules containing the mutant chain are incorporated into fibrils and that the absence of the telopeptide binding region from even a small portion of the monomers interferes with fibril growth.
Patent
Compositions and methods for detecting altered COL1A1 gene sequences
Darwin J. Prockop,Loretta D. Spotila,Constantinos D. Deltas,Larisa Sereda,Andrea Westerhausen Larson,Michael Pack,Alain Colige,James Early,Jarmo Körkkö,L. Ala-Kokko,Susanna Annunen,Tero Pihlajamaa,Mirko Vuoristo,Petteri Paassilta +13 more
TL;DR: In this article, the existence of a pathological condition associated with an altered gene encoding a Type I or Type IX collagen protein chain is identified, wherein such pathological conditions include diseases and disorders which are known to be associated with the altered gene.