Jason Borawski

TL;DR: The identification of patient stratification biomarkers for NVP-BGJ398, a novel and selective fibroblast growth factor receptor (FGFR) inhibitor, and it is shown that FGFR genetic alterations are the most significant predictors for sensitivity.

TL;DR: The results highlight the involvement of the ANO1 chloride channel in tumor progression and provide insights into oncogenic signaling in human cancers with 11q13 amplification, thereby establishing ANO 1 as a promising target for therapy in these highly prevalent tumor types.

TL;DR: It is shown that in a subset of highly sensitive tumor cell lines, activity of LBW242 is dependent on TNFalpha signaling, and Mechanistic studies indicate that in this context, XIAP is a positive modulator of T NFalpha induction whereas cellular inhibitor of apoptosis protein 1 negatively regulates TNF alpha-mediated apoptosis.

TL;DR: The data demonstrate that genetic or pharmacological modulation of PI4KA and PI4KB inhibits multiple genotypes of HCV and represents a novel druggable class of therapeutic targets for HCV infection.

TL;DR: Together, the experiments provide strong evidence that NIM811 reduces viral replication by inhibition of multiple cyclophilins and pathways with protein trafficking as the most strongly and persistently affected pathway.