A
Alan Huang
Researcher at Novartis
Publications - 63
Citations - 6110
Alan Huang is an academic researcher from Novartis. The author has contributed to research in topics: Cancer & PI3K/AKT/mTOR pathway. The author has an hindex of 27, co-authored 52 publications receiving 5026 citations.
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Journal ArticleDOI
Activation of MET via diverse exon 14 splicing alterations occurs in multiple tumor types and confers clinical sensitivity to MET inhibitors
Garrett M. Frampton,Siraj M. Ali,Margaret Rosenzweig,Juliann Chmielecki,Xinyuan Lu,Todd M. Bauer,Mikhail Akimov,Jose A. Bufill,Carrie B. Lee,David Jentz,Rick Hoover,Sai-Hong Ignatius Ou,Ravi Salgia,Tim Brennan,Zachary R. Chalmers,Savina Jaeger,Alan Huang,Julia A. Elvin,Rachel L. Erlich,Alex Fichtenholtz,Kyle Gowen,Joel R. Greenbowe,Adrienne Johnson,Depinder Khaira,Caitlin McMahon,Eric M. Sanford,Steven Roels,Jared White,Joel Greshock,Robert Schlegel,Doron Lipson,Roman Yelensky,Deborah Morosini,Jeffrey S. Ross,Eric A. Collisson,Malte Peters,Philip J. Stephens,Vincent A. Miller +37 more
TL;DR: Analysis of tumor genomic profiles from 38,028 patients is reported to identify 221 cases with METex14 mutations, including 126 distinct sequence variants, and identify a unique subset of patients likely to derive benefit from MET inhibitors.
Journal ArticleDOI
Identification and Characterization of NVP-BKM120, an Orally Available Pan-Class I PI3-Kinase Inhibitor
Sauveur-Michel Maira,Sabina Pecchi,Alan Huang,Matthew Burger,Mark Knapp,Dario Sterker,Christian Schnell,Daniel Guthy,Tobi Nagel,Marion Wiesmann,Saskia M. Brachmann,Christine Fritsch,Marion Dorsch,Patrick Chène,Kevin Shoemaker,Alain De Pover,Daniel Menezes,Georg Martiny-Baron,Doriano Fabbro,Christine D. Wilson,Robert Schlegel,Francesco Hofmann,Carlos Garcia-Echeverria,William R. Sellers,Charles Voliva +24 more
TL;DR: The biologic characterization of the 2-morpholino pyrimidine derivative pan-PI3K inhibitor NVP-BKM120 shows dose-dependent in vivo pharmacodynamic activity as measured by significant inhibition of p-Akt and tumor growth inhibition in mechanistic xenograft models and behaves synergistically when combined with either targeted agentssuch as MEK or HER2 inhibitors or with cytotoxic agents such as docetaxel or temozolomide.
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Relief of Profound Feedback Inhibition of Mitogenic Signaling by RAF Inhibitors Attenuates Their Activity in BRAFV600E Melanomas
Piro Lito,Christine A. Pratilas,Eric W. Joseph,Madhavi Tadi,Ensar Halilovic,Matthew Zubrowski,Alan Huang,Wai Lin Wong,Margaret K. Callahan,Taha Merghoub,Jedd D. Wolchok,Elisa de Stanchina,Sarat Chandarlapaty,Poulikos I. Poulikakos,James A. Fagin,Neal Rosen +15 more
TL;DR: BRAF(V600E) drives tumors by dysregulating ERK signaling, and its activation is Ras independent and it signals as a RAF-inhibitor-sensitive monomer, and combined inhibition results in enhancement of ERK pathway inhibition and antitumor activity.
Journal ArticleDOI
Convergent loss of PTEN leads to clinical resistance to a PI(3)Kα inhibitor
Dejan Juric,Pau Castel,Malachi Griffith,Obi L. Griffith,Helen Won,Haley Ellis,Saya H. Ebbesen,Benjamin J. Ainscough,Avinash Ramu,Gopa Iyer,Ronak Shah,Tiffany Huynh,Mari Mino-Kenudson,Dennis C. Sgroi,Steven J. Isakoff,Ashraf Thabet,Leila Elamine,David B. Solit,Scott W. Lowe,Cornelia Quadt,Malte Peters,Adnan Derti,Robert Schegel,Alan Huang,Elaine R. Mardis,Michael F. Berger,José Baselga,Maurizio Scaltriti +27 more
TL;DR: Tumour genomic evolution in a patient with metastatic breast cancer bearing an activating PIK3CA mutation is studied, concluding that parallel genetic evolution of separate metastatic sites with different PTEN genomic alterations leads to a convergent PTEN-null phenotype resistant to PI(3)Kα inhibition.
Journal ArticleDOI
Single-vector inducible lentiviral RNAi system for oncology target validation.
Dmitri Wiederschain,Susan Wee,Lin Chen,Alice Loo,Guizhi Yang,Alan Huang,Yan Chen,Giordano Caponigro,Yung Mae Yao,Christoph Lengauer,William R. Sellers,John D. Benson +11 more
TL;DR: The versatile and robust inducible lentiviral RNAi system reported herein can serve as a powerful tool to rapidly reveal tumor cell dependence.