1. Introduction and Overview. 2. Detecting Influential Observations and Outliers. 3. Detecting and Assessing Collinearity. 4. Applications and Remedies. 5. Research Issues and Directions for Extensions. Bibliography. Author Index. Subject Index.

Regression Diagnostics: Identifying Influential Data and Sources of Collinearity

Abbreviated Injury Scale

We show that the nonlinear mechanical response of networks formed from un–cross-linked fibrin or collagen type I continually changes in response to repeated large-strain loading. We demonstrate that this dynamic evolution of the mechanical response arises from a shift of a characteristic nonlinear stress–strain relationship to higher strains. Therefore, the imposed loading does not weaken the underlying matrices but instead delays the occurrence of the strain stiffening. Using confocal microscopy, we present direct evidence that this behavior results from persistent lengthening of individual fibers caused by an interplay between fiber stretching and fiber buckling when the networks are repeatedly strained. Moreover, we show that covalent cross-linking of fibrin or collagen inhibits the shift of the nonlinear material response, suggesting that the molecular origin of individual fiber lengthening may be slip of monomers within the fibers. Thus, a fibrous architecture in combination with constituents that exhibit internal plasticity creates a material whose mechanical response adapts to external loading conditions. This design principle may be useful to engineer novel materials with this capability.

https://www.pnas.org/content/pnas/110/30/12197.full.pdf

Strain history dependence of the nonlinear stress response of fibrin and collagen networks

Anterior cruciate ligament reconstruction is a frequently performed orthopaedic procedure. Although short-term results are generally good, long-term outcomes are less favorable. Thus, there is renewed interest in improving surgical techniques. Recent studies of anterior cruciate ligament anatomy and function have characterized the 2-bundle structure of the native ligament. During non-weightbearing conditions, the anteromedial (AM) and posterolateral (PL) bundles display reciprocal tension patterns. However, during weightbearing, both the AM and PL bundles are maximally elongated at low flexion angles and shorten significantly with increasing knee flexion. Conventional single-bundle reconstruction techniques often result in nonanatomic tunnel placement, with a tibial PL to a femoral “high AM” tunnel position. In vitro studies have demonstrated that these nonanatomic single-bundle reconstructions cannot completely restore normal anterior-posterior or rotatory laxity. Cadaveric studies suggest that anatomic ...

Anatomic Single- and Double-Bundle Anterior Cruciate Ligament Reconstruction, Part 1: Basic Science

The objective of this study was to develop full body CAD geometry of a seated 50th percentile male. Model development was based on medical image data acquired for this study, in conjunction with extensive data from the open literature. An individual (height, 174.9 cm, weight, 78.6 ± 0.77 kg, and age 26 years) was enrolled in the study for a period of 4 months. 72 scans across three imaging modalities (CT, MRI, and upright MRI) were collected. The whole-body dataset contains 15,622 images. Over 300 individual components representing human anatomy were generated through segmentation. While the enrolled individual served as a template, segmented data were verified against, or augmented with, data from over 75 literature sources on the average morphology of the human body. Non-Uniform Rational B-Spline (NURBS) surfaces with tangential (G1) continuity were constructed over all the segmented data. The sagittally symmetric model consists of 418 individual components representing bones, muscles, organs, blood vessels, ligaments, tendons, cartilaginous structures, and skin. Length, surface area, and volumes of components germane to crash injury prediction are presented. The total volume (75.7 × 103 cm(3)) and surface area (1.86 × 102 cm(2)) of the model closely agree with the literature data. The geometry is intended for subsequent use in nonlinear dynamics solvers, and serves as the foundation of a global effort to develop the next-generation computational human body model for injury prediction and prevention.

Development of a full body CAD dataset for computational modeling: a multi-modality approach

Test Methodology and Initial Results from a Dynamic Rollover Test System

This paper is from the SAE World Congress & Exhibition, held in April 2007 in Detroit, Michigan, USA. Part of the Pedestrian Safety session, this paper reports on a study of pedestrian kinematics with the Polar-II Finite Element Model. The authors describe how earlier studies on pedestrian-vehicle impact kinematics used post-mortem human surrogates (PMHS) and determined that vehicle shape may influence pedestrian kinematics and injury mechanisms. The authors describe finite element (FE) modeling as a more feasible approach, since numerous experiments can be conducted with a significantly lower cost. The authors report on their study which used an FE model of the Polar-II pedestrian dummy to evaluate the influence of shifting body contact points with respect to vehicle geometry on impact kinematics. Multiple simulations were performed by moving the pedestrian vertically with respect to the vehicle reference frame. Another component of the study was undertaken to evaluate the contribution of the mass distribution with respect to vehicle geometry. In this part, simulations were performed where the center of gravity of the dummy was shifted around the baseline location. The authors discuss the results of this study which suggest a nonlinear sensitivity of response to changes in the body contact points with respect to vehicle structures, as well as a linear variation of upper body trajectories when the dummy center of gravity height was adjusted.

Investigating Pedestrian Kinematics with the Polar-II Finite Element Model

Multidirectional mechanical properties and constitutive modeling of human adipose tissue under dynamic loading.

While one third of all fatal motor vehicle crashes involve rollover of the vehicle, a substantially large portion of these rollover crashes involve planar impacts (e.g., frontal, side or rear impact) that influence the crash kinematics and subsequently the injury outcome. The objective of the study was to evaluate the distribution of planar impacts in rollover crashes, and in particular, to describe the differences in the underlying crash kinematics, injury severity and the regional distribution of injuries when compared to the rollover-dominated crashes without significant planar impact (i.e., primary rollovers). Sampled cases (n=6,900) from the U.S. National Automotive Sampling System – Crashworthiness Data System, representing approximately 3.3 million belted drivers involved in a rollover crash in years 1998–2008, were analyzed. Single vehicle rollover crashes with significant planar impact (21% of all rollover crashes) were in general more likely to result in occupant fatality and involved higher incidence of moderate to severe injuries compared to single vehicle primary rollovers (p<0.05). A substantial proportion of the planar impact rollovers ended in single quarter turn crashes (30%), mostly resulting from a frontal impact (59%). While chest was the most frequently injured body region among all rollover victims sustaining severe injuries, severe injuries sustained in primary rollovers were more isolated (single body region) in comparison to the ones sustained in rollovers with planar impacts. The results emphasize the higher risk of rollover victims sustaining an injury and the differences in distribution of injuries sustained when a planar impact is associated with the rollover crash.

Jason R. Kerrigan

Papers

Test Methodology and Initial Results from a Dynamic Rollover Test System

Investigating Pedestrian Kinematics with the Polar-II Finite Element Model

Multidirectional mechanical properties and constitutive modeling of human adipose tissue under dynamic loading.

Planar impacts in rollover crashes: significance, distribution and injury epidemiology.

Material Identification using Successive Response Surface Methodology, with Application to a Human Femur Subjected to Three-Point Bending Loading