Showing papers by "Javed Iqbal published in 2003"
TL;DR: In this paper, an improved procedure for the synthesis of β-acetamido carbonyl compounds is developed by a cobalt(II) chloride-catalyzed three-component coupling protocol.
Abstract: An efficient improved procedure for the synthesis of β-acetamido carbonyl compounds is developed by a cobalt(II) chloride-catalyzed three-component coupling protocol. The procedure is also amenable to the synthesis of γ-lactams by a three-component coupling reaction with use of 2-carbomethoxybenzaldehyde. The β-acetamido carbonyl compounds derived from 2-carbomethoxybenzaldehyde are useful intermediates as they can be transformed to the corresponding γ-lactams on treatment with base.
90 citations
TL;DR: In this article, a 3-bromobenzyl group at C-termini and an acryloyl group at N termini were used to synthesize cyclic peptides.
27 citations
TL;DR: A series of phenyl acetic acid and alpha-hydroxy propionic acid derivatives were synthesized and in vivo studies of the compounds indicated compound 2c as the most potent in one of the series.
12 citations
3 citations
TL;DR: In this article, a 3-bromobenzyl group at C-termini and an acryloyl group at N termini were used to synthesize cyclic peptides.
Abstract: Tripeptides having a 3-bromobenzyl group at the C-termini and an acryloyl group at the N termini undergo efficient intramolecular Heck reactions to afford the corresponding cyclic peptides in good yields. Synthesis of two such peptides is discussed.
1 citations
TL;DR: In this paper, an improved procedure for the synthesis of β-acetamido carbonyl compounds is developed by a cobalt(II) chloride-catalyzed three-component coupling protocol.
Abstract: An efficient improved procedure for the synthesis of β-acetamido carbonyl compounds is developed by a cobalt(II) chloride-catalyzed three-component coupling protocol. The procedure is also amenable to the synthesis of γ-lactams by a three-component coupling reaction with use of 2-carbomethoxybenzaldehyde. The β-acetamido carbonyl compounds derived from 2-carbomethoxybenzaldehyde are useful intermediates as they can be transformed to the corresponding γ-lactams on treatment with base.
1 citations
1 citations
TL;DR: Cis-4-Amino-L-proline derivatives 1 and 2 derived from quinazolinone and pyrazolo pyrimidone respectively were designed as novel lipid lowering agents as mentioned in this paper.
Abstract: cis-4-Amino-L-proline derivatives 1 and 2 derived from quinazolinone and pyrazolo pyrimidone respectively were designed as novel lipid lowering agents. A preliminary in vivo screening indicates that 1b and 2a have moderate triglyceride lowering activity.
TL;DR: In this paper, a series of phenyl acetic acid and α-hydroxy propionic acid derivatives were synthesized and in vivo studies indicated compound 2c as the most potent in one of the series, which has both glucose and lipid lowering properties.
Abstract: A series of phenyl acetic acid and α-hydroxy propionic acid derivatives were synthesized. In vivo studies of the compounds indicated compound 2c as the most potent in one of the series, which has both glucose and lipid lowering properties. The syntheses and biological studies have been discussed.