Showing papers by "Javier Díaz-Nido published in 2007"

TL;DR: This study shows that BDNF production by OECs plays a direct role in the promotion of axon regeneration of adult CNS neurons.

TL;DR: It is shown that frataxin expression can be eliminated in neurons from these loxP[frda] mice by infection with CRE-expressing herpes simplex virus type 1 (HSV-1) amplicon vectors, the first proof of principle of recovery of neurological function by a therapeutic agent aimed at correcting fr ataxin deficiency.

TL;DR: The construction and delivery of high capacity herpes simplex virus type 1 (HSV-1) amplicon vectors expressing the entire FRDA genomic locus, driven by the endogenous FRDA promoter and including all introns and flanking regulatory sequences within a 135 kb genomic DNA insert are described.

TL;DR: It is demonstrated that the expression of a dominant-negative form of glycogen synthase kinase-3 protects Purkinje neurons against cell death triggered by a chemical inhibitor of phosphatidylinositol-3 kinase, which enables gene transfer studies to be carried out using herpesviral vectors.