J
Javier Valle
Researcher at Barcelona Biomedical Research Park
Publications - 32
Citations - 445
Javier Valle is an academic researcher from Barcelona Biomedical Research Park. The author has contributed to research in topics: Peptide & Antimicrobial. The author has an hindex of 8, co-authored 25 publications receiving 279 citations. Previous affiliations of Javier Valle include Johns Hopkins University School of Medicine & Pompeu Fabra University.
Papers
More filters
Journal ArticleDOI
The Generation of Antimicrobial Peptide Activity: A Trade-off between Charge and Aggregation?†
TL;DR: The residue-intrinsic propensities for both properties, that is, the probability for an individual residue to be located in either aggregation-prone or antimicrobial domains, are well correlated and suggest that they may be somehow related.
Journal ArticleDOI
Rapid Loss of RNA Detection by In Situ Hybridization in Stored Tissue Blocks and Preservation by Cold Storage of Unstained Slides
Javier Valle,Qizhi Zheng,Jessica Hicks,Helen Fedor,Bruce J. Trock,Colm Morrissey,Eva Corey,Toby C. Cornish,Karen S. Sfanos,Angelo M. De Marzo +9 more
TL;DR: Storing unstained slides cut from recent cases at -20°C can preserve hybridization signals significantly better than storing the blocks at room temperature and cutting the slides fresh when needed to better preserve RNA for in situ hybridization.
Journal ArticleDOI
Mannose Receptor-positive Macrophage Infiltration Correlates with Prostate Cancer Onset and Metastatic Castration-resistant Disease.
Jelani C. Zarif,Jelani C. Zarif,Javier Valle,Jessica L. Hicks,Christopher M. Heaphy,Christopher M. Heaphy,Igor Vidal,Jacob Luo,Tamara L. Lotan,Jody E. Hooper,William B. Isaacs,William B. Isaacs,Kenneth J. Pienta,Kenneth J. Pienta,Angelo M. De Marzo,Angelo M. De Marzo +15 more
TL;DR: The results provide a rationale for therapeutic targeting of macrophages in the PC microenvironment as a potential method to augment immunotherapeutic responses and help explain the lack of clinical success of immunotherapy for PC patients.
Journal ArticleDOI
MYC drives overexpression of telomerase RNA (hTR/TERC) in prostate cancer
Javier Valle,Qizhi Zheng,David M. Esopi,Michael Rubenstein,Gretchen K. Hubbard,Maria C Moncaliano,Andrew Hruszkewycz,Ajay Vaghasia,Srinivasan Yegnasubramanian,Sarah J. Wheelan,Alan K. Meeker,Christopher M. Heaphy,Mindy K. Graham,Angelo M. De Marzo +13 more
TL;DR: It is reported that TERC is consistently overexpressed in all stages of prostatic adenocarcinoma and that its expression is regulated by MYC, which nominates TERC as a novel prostate cancer biomarker and therapeutic target.
Journal ArticleDOI
Ribonucleases as a host-defence family: evidence of evolutionarily conserved antimicrobial activity at the N-terminus
Marc Torrent,Marc Torrent,David Pulido,Javier Valle,M. Victòria Nogués,David Andreu,Ester Boix +6 more
TL;DR: It is suggested that a defence mechanism could be a primary function in vertebrate RNases and that the N-terminus was selected to ensure this property, and general correlation rules could be drawn to assist in the structure-based development of antimicrobial agents.