J
Javiera Espoz
Researcher at Leiden University
Publications - 2
Citations - 237
Javiera Espoz is an academic researcher from Leiden University. The author has contributed to research in topics: Catharanthus & Iridoid. The author has an hindex of 2, co-authored 2 publications receiving 179 citations.
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Journal ArticleDOI
The bHLH transcription factor BIS1 controls the iridoid branch of the monoterpenoid indole alkaloid pathway in Catharanthus roseus
Alex Van Moerkercke,Alex Van Moerkercke,Priscille Steensma,Fabian Schweizer,Fabian Schweizer,Jacob Pollier,Jacob Pollier,Ivo Gariboldi,Richard J. Payne,Robin Vanden Bossche,Robin Vanden Bossche,Karel Miettinen,Karel Miettinen,Javiera Espoz,Purin Candra Purnama,Franziska Kellner,Tuulikki Seppänen-Laakso,Sarah E. O'Connor,Heiko Rischer,Johan Memelink,Alain Goossens,Alain Goossens +21 more
TL;DR: A master regulator was discovered that activates the biosynthesis of the iridoids, the monoterpenoid precursors of vinblastine and vincristine, and the rate-limiting branch in their biosynthetic pathway and represents an interesting tool for the metabolic engineering of the sustainable production of these high-value compounds in cultures of the endogenous plant species.
Journal ArticleDOI
The basic helix-loop-helix transcription factor BIS2 is essential for monoterpenoid indole alkaloid production in the medicinal plant Catharanthus roseus.
Alex Van Moerkercke,Priscille Steensma,Ivo Gariboldi,Javiera Espoz,Purin Candra Purnama,Fabian Schweizer,Karel Miettinen,Robin Vanden Bossche,Rebecca De Clercq,Johan Memelink,Alain Goossens +10 more
TL;DR: The identification and characterisation of BIS2 is described, a jasmonate (JA)-responsive bHLH TF expressed preferentially in internal phloem-associated parenchyma cells, which transactivates promoters of iridoid biosynthesis genes and can homodimerise or form heterodimers with BIS1.