J
Jean-Christophe Giard
Researcher at University of Caen Lower Normandy
Publications - 74
Citations - 2990
Jean-Christophe Giard is an academic researcher from University of Caen Lower Normandy. The author has contributed to research in topics: Enterococcus faecalis & Virulence. The author has an hindex of 32, co-authored 70 publications receiving 2694 citations. Previous affiliations of Jean-Christophe Giard include University of British Columbia & Institut national de la recherche agronomique.
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Journal ArticleDOI
Survival of Enterococcus faecalis in an Oligotrophic Microcosm: Changes in Morphology, Development of General Stress Resistance, and Analysis of Protein Synthesis
TL;DR: The combined data suggest that energy starvation induces a response similar to that triggered by oligotrophy, which seems to play a key role in the observed phenomena of long-term survival and development of general stress resistance of starved cultures of E. faecalis.
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Relationship between stress response towards bile salts, acid and heat treatment in Enterococcus faecalis
Sigrid Flahaut,Axel Hartke,Jean-Christophe Giard,Abdellah Benachour,Philippe Boutibonnes,Yanick Auffray +5 more
TL;DR: Stress tolerance and cross-protection in Enterococcus faecalis ATCC19433 were examined after exposure to bile salts, acid or heat shock and whole-cell protein extract analysis revealed that each treatment induced a battery of stress proteins.
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The Lactic Acid Stress Response of Lactococcus lactis subsp. lactis
Axel Hartke,Sandrine Bouche,Jean-Christophe Giard,Abdellah Benachour,Philippe Boutibonnes,Yanick Auffray +5 more
TL;DR: The results establish that L. lactis can adapt to lactic acid exposure in two different ways: a logarithmic phase LATR, which may be activated by protons, and a stationary-phase LATR which needs no activation by protONS.
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Comparative study of the physiological roles of three peroxidases (NADH peroxidase, Alkyl hydroperoxide reductase and Thiol peroxidase) in oxidative stress response, survival inside macrophages and virulence of Enterococcus faecalis
Stéphanie La Carbona,Nicolas Sauvageot,Jean-Christophe Giard,Abdellah Benachour,Brunella Posteraro,Yanick Auffray,Maurizio Sanguinetti,Axel Hartke +7 more
TL;DR: Analysis of the survival of the different strains inside peritoneal macrophages revealed that Tpx was the most important antioxidant activity for protecting the cells against the hostile phagocyte environment.
Journal ArticleDOI
The stress proteome of Enterococcus faecalis.
Jean-Christophe Giard,Jean-Marie Laplace,Alain Rincé,Vianney Pichereau,Abdellah Benachour,Céline Leboeuf,Sigrid Flahaut,Yanick Auffray,Axel Hartke +8 more
TL;DR: A comprehensive description of stress proteins of E. faecalis and analysis of their patterns of expression under different environmental conditions would greatly increase the understanding of the molecular mechanisms underlying the extraordinary capacity of this bacterium to survive under hostile conditions.