J
Jean-Dominique Vassalli
Researcher at University of Geneva
Publications - 63
Citations - 7748
Jean-Dominique Vassalli is an academic researcher from University of Geneva. The author has contributed to research in topics: Plasminogen activator & Plasmin. The author has an hindex of 39, co-authored 63 publications receiving 7631 citations. Previous affiliations of Jean-Dominique Vassalli include Tohoku University & International Institute of Minnesota.
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Journal ArticleDOI
The plasminogen activator/plasmin system.
TL;DR: The evidence that supports the contention that plasminogen activators and inhibitors are key participants in the balance of proteolytic and antiproteolytic activities that regulates matrix turnover is summarized and the role ofpecific cell surface binding sites is discussed.
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The receptor for urokinase type plasminogen activator polarizes expression of the protease to the leading edge of migrating monocytes and promotes degradation of enzyme inhibitor complexes.
TL;DR: Results indicate that the uPA receptor can function both to focus plasmin-mediated extracellular matrix degradation in front of migrating cells, and to target uPA/PAI-2 enzyme/inhibitor complexes for degradation; they suggest that this receptor is a key determinant in the control of uPA-catalyzed extrace cellular proteolysis.
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Transforming growth factor-beta 1 modulates basic fibroblast growth factor-induced proteolytic and angiogenic properties of endothelial cells in vitro.
TL;DR: A novel perspective is provided on the relationship between extracellular matrix invasion, lumen formation, and net proteolytic balance, thereby reflecting the interplay between angiogenesis-modulating cytokines such as bFGF and TGF-beta 1.
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Amiloride selectively inhibits the urokinase-type plasminogen activator
TL;DR: The diuretic drug amiloride, an inhibitor of Na+ uptake, competitively inhibits the catalytic activity of the urokinase‐type plasminogen activator (u‐PA), and may be related to the previously reported inhibition of u‐PA‐type enzymes by Na+.
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Extracellular proteolysis in the adult murine brain.
André-Pascal Sappino,Rime Madani,Joachim Huarte,Dominique Belin,Jozsef Zoltan Kiss,Annelise Isabelle Wohlwend,Jean-Dominique Vassalli +6 more
TL;DR: Observations indicate that tissue-type plasminogen activator-catalyzed proteolysis in neural tissues is not limited to ontogeny, but may also contribute to adult central nervous system physiology, for instance by influencing neuronal plasticity and synaptic reorganization.