J
Jean Marie Deminière
Researcher at French Institute of Health and Medical Research
Publications - 5
Citations - 1792
Jean Marie Deminière is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Amphetamine & Addiction. The author has an hindex of 5, co-authored 5 publications receiving 1762 citations. Previous affiliations of Jean Marie Deminière include University of Bordeaux.
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Journal ArticleDOI
Stress- and pharmacologically-induced behavioral sensitization increases vulnerability to acquisition of amphetamine self-administration
TL;DR: It is shown that vulnerability to develop amphetamine SA may be influenced by stressful experiences, and that previous contact with the drug may enhance a predisposition to amphetamine-taking behavior.
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Corticosterone levels determine individual vulnerability to amphetamine self-administration.
Pier Vincenzo Piazza,Stefania Maccari,Jean Marie Deminière,M. Le Moal,Pierre Mormède,H. Simon +5 more
TL;DR: The results indicate that the stress-related activity of the hypothalamic-pituitary-adrenal axis may play a role in the pathogenesis of psychostimulant addiction.
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Dopaminergic activity is reduced in the prefrontal cortex and increased in the nucleus accumbens of rats predisposed to develop amphetamine self-administration.
Pier Vincenzo Piazza,Françoise Rougé-Pont,Jean Marie Deminière,Martine Kharoubi,Michel Le Moal,H. Simon +5 more
TL;DR: The HR rats displayed a specific neurochemical pattern: a higher DOPAC/DA ratio in the nucleus accumbens and striatum and a lower one in the prefrontal cortex, corresponding to the mean of these compounds for the three structures studied over the three environmental conditions.
Journal ArticleDOI
Increased locomotor response to novelty and propensity to intravenous amphetamine self-administration in adult offspring of stressed mothers
Jean Marie Deminière,Pier Vincenzo Piazza,Gilles Guegan,Nora Abrous,Stefania Maccari,Michel Le Moal,Hervé Simon +6 more
TL;DR: It is shown that prenatal stress (restraint of the mother during the last week of pregnancy) may contribute to an individual's vulnerability to develop amphetamine self-administration.
Journal ArticleDOI
Hippocampal type I and type II corticosteroid receptor affinities are reduced in rats predisposed to develop amphetamine self-administration.
Stefania Maccari,Pier Vincenzo Piazza,Jean Marie Deminière,Luciano Angelucci,H. Simon,Michel Le Moal +5 more
TL;DR: Differences in affinities suggest a relation among amphetamine self-administration, control of the corticosterone feedback loop, serum levels of cortic testosterone and characteristics of hippocampal corticosteroid receptors, and the implication is that pharmacological manipulations of Corticosteroids receptors may reveal new therapeutic strategies for drug abuse.